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http://hdl.handle.net/11189/6670| Title: | 2α-Acetoxy-15-acetylartemisiifolin, a new Anti-trypanosomal Sesquiterpene Lactone from Mikania guaco | Authors: | Hussein, Ahmed A Romero, L Lopez-Perez, Jose Luis Gupta, Mahabir Prashad |
Keywords: | Methanol extract;Trypanosoma cruzi;Mass spectrometry;Sesquiterpene lactone;Mikania guaco | Issue Date: | 2017 | Publisher: | Natural Product Inc. | Journal: | Natural Product Communications | Abstract: | Mikania guaco Bonpl. methanol extract showed an interesting activity against Trypanosoma cruzi with an IC50 of 4 μg/mL. Bioassay-guided fractionation of the methanol extract resulted in the isolation of a new sesquiterpene lactone, 2α-acetoxy,15-acetylartemisiifolin (1), which was shown to be active (IC50 = 25 μM) against the amastigote form of T. cruzi. The chemical structure of 1 was elucidated using 2-D NMR techniques and mass spectrometry. | Description: | Article | URI: | http://hdl.handle.net/11189/6670 |
| Appears in Collections: | Appsc - Journal Articles (DHET subsidised) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Hussein_Ahmed_A_Romero_Luz_López-Pérez_Jose_Luis_Gupta__Mahabir_P_AppSci_2016.pdf | Article | 226.36 kB | Adobe PDF | View/Open |
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