Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6670
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dc.contributor.authorHussein, Ahmed Aen_US
dc.contributor.authorRomero, Len_US
dc.contributor.authorLopez-Perez, Jose Luisen_US
dc.contributor.authorGupta, Mahabir Prashaden_US
dc.date.accessioned2018-11-02T07:21:47Z-
dc.date.available2018-11-02T07:21:47Z-
dc.date.issued2017-
dc.identifier.urihttp://hdl.handle.net/11189/6670-
dc.descriptionArticleen_US
dc.description.abstractMikania guaco Bonpl. methanol extract showed an interesting activity against Trypanosoma cruzi with an IC50 of 4 μg/mL. Bioassay-guided fractionation of the methanol extract resulted in the isolation of a new sesquiterpene lactone, 2α-acetoxy,15-acetylartemisiifolin (1), which was shown to be active (IC50 = 25 μM) against the amastigote form of T. cruzi. The chemical structure of 1 was elucidated using 2-D NMR techniques and mass spectrometry.en_US
dc.language.isoenen_US
dc.publisherNatural Product Inc.en_US
dc.relation.ispartofNatural Product Communicationsen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.subjectMethanol extracten_US
dc.subjectTrypanosoma cruzien_US
dc.subjectMass spectrometryen_US
dc.subjectSesquiterpene lactoneen_US
dc.subjectMikania guacoen_US
dc.title2α-Acetoxy-15-acetylartemisiifolin, a new Anti-trypanosomal Sesquiterpene Lactone from Mikania guacoen_US
dc.type.patentArticleen_US
Appears in Collections:Appsc - Journal Articles (DHET subsidised)
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