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Title: Kinetic modelling and optimisation of antimicrobial compound production by candida pyralidae KU736785 for control of candida guilliermondii
Authors: Mewa-Ngongang, Maxwell 
Du Plessis, HW 
Hutchinson, UF 
Mekuto, Lukhanyo 
Ntwampe, Seteno Karabo Obed 
Keywords: Antimicrobial compounds;Candida pyralidae;Candida guilliermondii;Central composite design;Inhibitory activity;Response surface methodology
Issue Date: 2017
Publisher: Sage
Source: Mewa-Ngongang, M.,du Plessis, . W., Hutchinson, U. F. Mekuto, L., Ntwampe, S.K.O. 2017. Kinetic modelling and optimisation of antimicrobial compound production by candida pyralidae KU736785 for control of candida guilliermondii. Food Science and Technology International. 1-13
Abstract: Biological antimicrobial compounds from yeast can be used to address the critical need for safer preservatives in food, fruit and beverages. The inhibition of Candida guilliermondii, a common fermented beverage spoilage organism, was achieved using antimicrobial compounds produced by Candida pyralidae KU736785. The antimicrobial production system was modelled and optimised using response surface methodology, with 22.5 C and pH of 5.0 being the optimum conditions. A new concept for quantifying spoilage organism inhibition was developed. The inhibition activity of the antimicrobial compounds was observed to be at a maximum after 17–23 h of fermentation, with C. pyralidae concentration being between 0.40 and 1.25 109 CFU ml 1, while its maximum specific growth rate was 0.31–0.54 h 1. The maximum inhibitory activity was between 0.19 and 1.08 l contaminated solidified media per millilitre of antimicrobial compound used. Furthermore, the antimicrobial compound formation rate was 0.037–0.086 l VZI ml 1 ACU h 1, respectively. The response surface methodology analysis showed that the model developed sufficiently described theantimicrobial compound formation rate 1.08 l VZI ml 1 ACU, as 1.17 l VZI ml 1 ACU, predicted under the optimum production conditions.
Appears in Collections:Appsc - Journal Articles (DHET subsidised)
Prof. Seteno Karabo Ntwampe
BioERG - Journal articles (DHET subsidised)

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