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Title: Association of cocaine- and amphetamine- related transcript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in South African
Authors: Yako, Yandiswa Y 
Fanampe, Biotumelo L 
Hassan, Mogamat Shafick 
Erasmus, Rajiv Timothy 
Van der Merwe, L 
Van Rensburg, Susan Janse 
Matsha, Tandi Edith 
Keywords: Association of cocaine;Association of amphetamine;Gene polymorphisms;Anthropometric obesity phenotype;South African learners;South Africa;Obesity
Issue Date: 2011
Publisher: Karger
Abstract: Background/Aims: Obesity has increased rapidly in South African children and adolescents. Genes involved in appetite regulation have been extensively studied worldwide, but their role in the obesity phenotype in South African Black and mixed-ancestry school adolescents is unknown. Methods: Seven common polymorphisms in LEP, GHRL, CART and LEPR were analysed for genotype and haplotype association with anthropometric obesity phenotype indicators in South African Black and mixed-ancestry adolescent school learners. Results: The CART c.517A→G polymorphism was significantly associated with obesity susceptibility. The LEPR Lys109Arg G allele was associated with an average reduction of 2.36 kg/m2 in body mass index (BMI), 5.66 cm in waist circumference (WC) and 1.61 cm in mid-upper-arm circumference (MUAC). This was confirmed by haplotype analysis. Additionally, a haplotype of the LEP polymorphisms significantly increased BMI, MUAC and hip circumference, while LEPR haplotypes were associated with differences in MUAC. Conclusion: Our findings suggest that c.517A→G and Lys109Arg contribute to the variation in anthropometric obesity phenotype indicators observed among Black African and mixed-ancestry South African learners. Furthermore, haplotypes of LEP, LEPR and GHRL polymorphisms were associated with varying measurements of weight, BMI and WC. Further studies are required to confirm our results in a larger and homogeneous study population group.
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
Prof. Thandi Matsha

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