Associations of leucocyte telomere length with cardio-metabolic risk profile in a South African HIV-infected population

Abstract

Leukocyte Telomere length (LTL) is an independent predictor of cardio-metabolic diseases (CMDs) and Human Immuno Virus (HIV) infection. However, studies are lacking on the association between LTL with CMD profile in people with HIV. Accordingly, we investigated the association between LTL and CMD profile in HIV-infected adult South Africans. This cross-sectional study included 728 HIV patients (20.6% men; median age 38years) recruited across 17 public healthcare facilities in Cape Town. CMD markers were compared across quartiles of LTL, and spearman correlations assessed the continuous association of LTL with CMD markers. Linear and logistic regressions were then used to relate LTL with CMD risk profile, with appropriate adjustment for confounders. The prevalence of obesity, hypertension and diabetes were 34.8%, 36.8%, and 8.4%, respectively. In age, sex and body mass index adjusted models, increasing Log10LTL was associated with decreasing systolic (b= 10.52) and diastolic (b= 6.74) blood pressures, HOMA-b (b= 70.72), increasing total cholesterol (b=0.544), non-high-density lipoprotein cholesterol (b=0.472), and waist-to-height-ratio>0.5 (odds ratio [OR]=5.67), all P<.05. Compared to those in the bottom quarter, those in the top LTL quarter had lower prevalence of hypertension (OR=0.65), and higher prevalence of total cholesterol>5mmol/L (OR=1.94), and low-density lipoprotein-cholesterol>3mmol/L (OR=1.62), all P<.05. LTL was not associated with diabetes nor general obesity. It was associated with Alanine Transaminase (ALT) and heart rate in univariable analyses. LTL shortening was associated with some CMD risk factors in HIV-infected adults on anti-retroviral therapy in South Africa. Prospective research is needed to explore the direction and implications of these associations.