Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/8766
Title: Antimycobacterial, cytotoxic, and antioxidant activities of Abietane Diterpenoids isolated from Plectranthus madagascariensis
Authors: Ndjoubi, Kadidiatou O. 
Sharma, Rajan 
Badmus, Jelili A. 
Jacobs, Ayesha 
Jordaan, Audrey 
Marnewick, Jeanine L 
Warner, Digby F. 
Hussein, Ahmed A. 
Keywords: Plectranthus madagascariensis;abietane diterpenoids;tuberculosis;antioxidant;cytotoxicity
Issue Date: 2021
Publisher: MDPI
Source: Ndjoubi, K.O., Sharma, R., Badmus, J.A. et al. 2021. Antimycobacterial, cytotoxic, and antioxidant activities of Abietane Diterpenoids isolated from Plectranthus madagascariensis. Plants, 10: 175. [https://doi.org/ 10.3390/plants10010175]
Journal: Plants 
Abstract: Medicinal plants of the Plectranthus genus (Lamiaceae) are well known for their ethnomedicinal applications. Plectranthus madagascariensis, which is native to South Africa, is traditionally used in the treatment of respiratory conditions, scabies, and cutaneous wounds. The phytochemical studies of P. madagascariensis led to the isolation of five known royleanone abietanes, namely, 6β,7αdihydroxyroyleanone (1), 7α-acetoxy-6β-hydroxyroyleanone (2), horminone (3), coleon U quinone (4), and carnosolon (5). The relative configuration of compound 2 was established by X-ray analysis. Compounds 1–4 showed antimycobacterial activity (Minimum inhibitory concentration for 90% inhibition, MIC90 = 5.61–179.60 µM) against Mycobacterium tuberculosis H37Rv. Compound 4 and 5 showed comparable toxicity (Concentration for 50% inhibition, IC50 98.49 µM and 79.77 µM) to tamoxifen (IC50 22.00 µg/mL) against HaCaT cells. Compounds 1–5 showed antioxidant activity through single-electron transfer (SET) and/or hydrogen-atom transfer (HAT) with compound 5 being the most active antioxidant agent. Compounds 3 and 5 were isolated for the first time from P. madagascariensis. The observed results suggest P. madagascariensis as an important ethnomedicinal plant and as a promising source of diterpenoids with potential use in the treatment of tuberculosis and psoriasis.
Description: Article
URI: http://hdl.handle.net/11189/8766
ISSN: 2223-7747
DOI: https://doi.org/ 10.3390/plants10010175
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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