Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/8563
Title: Green synthesis of gold nanoparticles capped with procyanidins from leucosidea sericea as potential antidiabetic and antioxidant agents
Authors: Badeggi, Umar Muhammad 
Ismail, Enas 
Adeloye, Adewale O. 
Botha, Subelia S. 
Badmus, Jelili A. 
Marnewick, Jeanine L 
Cupido Christopher N 
Hussein, Ahmed A 
Keywords: Leucosidea sericea;alpha-amylase;alpha-glucosidase;diabetics;gold nanoparticles
Issue Date: 2020
Publisher: MDPI
Source: Badeggi. U.M., Ismail E., Adeloye. A.O. et al. 2020. Green synthesis of gold nanoparticles capped with procyanidins from leucosidea sericea as potential antidiabetic and antioxidant agents. Biomolecules. 10(3): 452. [https://doi.org/10.3390/biom10030452]
Journal: Biomolecules 
Abstract: In this study, procyanidins fractions of dimers and trimers (F1–F2) from the Leucosidea sericea total extract (LSTE) were investigated for their chemical constituents. The total extract and the procyanidins were employed in the synthesis of gold nanoparticles (Au NPs) and fully characterized. Au NPs of 6, 24 and 21 nm were obtained using LSTE, F1 and F2 respectively. Zeta potential and in vitro stability studies confirmed the stability of the particles. The enzymatic activity of LSTE, F1, F2 and their corresponding Au NPs showed strong inhibitory alpha-amylase activity where F1 Au NPs demonstrated the highest with IC50 of 1.88 µg/mL. On the other hand, F2 Au NPs displayed the strongest alpha-glucosidase activity at 4.5 µg/mL. F2 and F2 Au NPs also demonstrated the highest antioxidant activity, 1834.0 ± 4.7 μM AAE/g and 1521.9 ± 3.0 μM TE/g respectively. The study revealed not only the ability of procyanidins dimers (F1 and F2) in forming biostable and bioactive Au NPs but also, a significant enhancement of the natural products activities, which could improve the smart delivery in future biomedical applications.
URI: http://hdl.handle.net/11189/8563
ISSN: 2218-273X
DOI: https://doi.org/10.3390/biom10030452
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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