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|Title:||Associations between body fat distribution and cardiometabolic risk factors in mixed-ancestry South African women and men||Authors:||Davidson, Florence E.
Matsha, Tandi Edith
Erasmus, Rajiv T
Kengne, Andre Pascal
Goedecke, Julia H.
|Keywords:||DXA;visceral adipose tissue;subcutaneous adipose tissue;menopause;ethnicity;gender;cardiometabolic risk||Issue Date:||2019||Publisher:||PASCAR||Source:||Davidson, F. E., Matsha, T. E., Erasmus, R. T. 2019. Associations between body fat distribution and cardiometabolic risk factors in mixed-ancestry South African women and men. Cardiovascular Journal of Africa, 30(6): 321-330. [http://doi.org/ 10.5830/CVJA-2019-028]||Journal:||Cardiovascular Journal of Africa||Abstract:||Objective: To investigate the relationship between body fat distribution and cardiometabolic risk in mixed-ancestry South African (SA) men and women, and to explore the effect of menopausal status on these relationships in women. Methods: In a cross-sectional study, 207 mixed-ancestry SA women and 46 men underwent measurement of body composition using dual-energy X-ray absorptiometry, blood pressure, oral glucose tolerance, lipid profile and high-sensitivity C-reactive protein determination. The associations between different body fat compartments and associated cardiometabolic risk factors were explored. Results: Men had less percentage fat mass (%FM) [26.5% (25–75th percentiles: 19.9–32.5) vs 44.0% (39.8–48.6), p ≤ 0.001], but more central and less peripheral fat (both p < 0.001) than women. Post-menopausal women had greater %FM, waist and visceral adipose tissue (VAT), and less gynoid %FM than pre-menopausal women (all p ≤ 0.004). After adjusting for age and gender, VAT accounted for the greatest variance in insulin resistance (R2 = 0.27), while trunk %FM and leg %FM accounted for the greatest variance in triglyceride (R2 = 0.13) and high-density lipoprotein cholesterol concentrations (R2 = 0.14). The association between fat mass and regional subcutaneous adipose tissue and cardiometabolic risk factors differed by gender and menopausal status. Conclusion: Central fat was the most significant correlate of cardiometabolic risk and lower body fat was associated with reduced risk. These relationships were influenced by gender and menopausal status.||URI:||http://hdl.handle.net/11189/8370||ISSN:||1995-1892
|Appears in Collections:||HWSci - Journal Articles (DHET subsidised)|
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