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http://hdl.handle.net/11189/7585| Title: | Co-crystals and co-crystal hydrates of vanillic acid | Authors: | Jacobs, Ayesha Noa, Francoise M. Amombo |
Keywords: | Crystal engineering;co-crystals of vanillic acid;theophylline;isonicotinamide;methylated xanthines | Issue Date: | 2015 | Publisher: | Royal Society of Chemistry | Source: | Jacobs, A. & Amombo Noa, F. M. 2015. Co-crystals and co-crystal hydrates of vanillic acid. CrystEngComm, 17: 98-106. [http://doi.org/10.1039/c4ce01795a] | Journal: | CrystEngComm | Abstract: | A series of co-crystals of vanillic acid (VA) with caffeine (CAF), theophylline (THP), theobromine (THB), nicotinamide (NAM), isonicotinamide (INM), acridine (ACR) and urea (U) have successfully been prepared. The co-crystals involving the methylated xanthines indicate different host: guest ratios with co-crystals VA·2CAF, 2VA·THP and the co-crystal hydrate VA·THB·2H2O. The nicotinamide and acridine co-crystals (VA·NAM and VA·ACR) displayed 1 : 1 molar ratios in contrast to the isonicotinamide co-crystal hydrate 2VA·2INM·2H2O. Co-crystallisation of vanillic acid with urea gave 2VA·2U. The co-crystals and co-crystal hydrates were characterised by single crystal X-ray diffraction and thermal analysis. Grinding and slurry experiments were also performed | URI: | http://hdl.handle.net/11189/7585 | ISSN: | 1466-8033 | DOI: | http://doi.org/10.1039/c4ce01795a |
| Appears in Collections: | Appsc - Journal Articles (DHET subsidised) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Co-crystals and co-crystal hydrates of vanillic acid.pdf | 2.31 MB | Adobe PDF | View/Open |
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