Please use this identifier to cite or link to this item:
Title: Inhibition of bacteria associated with wound infection by Biocompatible Green Synthesized Gold Nanoparticles from South African Plant Extracts
Authors: Elbagory, Abdulrahman M 
Meyer, Mervin 
Cupido, Christopher N 
Hussein, Ahmed A 
Keywords: Gold nanoparticles;green nanotechnology;Galenia africana;Hypoxis hemerocallidea;antibacterial activity;Alamar blue;MTT;HRTEM
Issue Date: 2017
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Source: Elbagory, A. M., Meyer, M., Cupido, C. et al. 2017. Inhibition of bacteria associated with wound infection by Biocompatible Green Synthesized Gold Nanoparticles from South African Plant Extracts. Nanomaterials, 7(417): 22 pages. []
Journal: Nanomaterials 
Abstract: Unlike conventional physical and chemical methods, the biogenic synthesis of gold nanoparticles (GNPs) is considered a green and non-toxic approach to produce biocompatible GNPs that can be utilized in various biomedical applications. This can be achieved by using plant-derived phytochemicals to reduce gold salt into GNPs. Several green synthesized GNPs have been shown to have antibacterial effects, which can be applied in wound dressings to prevent wound infections. Therefore, the aim of this study is to synthesize biogenic GNPs from the South African Galenia africana and Hypoxis hemerocallidea plants extracts and evaluate their antibacterial activity, using the Alamar blue assay, against bacterial strains that are known to cause wound infections. Additionally, we investigated the toxicity of the biogenic GNPs to non-cancerous human fibroblast cells (KMST-6) using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. In this paper, spherical GNPs, with particle sizes ranging from 9 to 27 nm, were synthesized and fully characterized. The GNPs from H. hemerocallidea exhibited antibacterial activity against all the tested bacterial strains, whereas GNPs produced from G. africana only exhibited antibacterial activity against Pseudomonas aeruginosa. The GNPs did not show any significant toxicity towards KMST-6 cells, which may suggest that these nanoparticles can be safely applied in wound dressings
ISSN: 2079-4991
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Inhibition of Bacteria Associated with Wound Infection.pdf6.28 MBAdobe PDFView/Open
Show full item record

Page view(s)

checked on Feb 9, 2021


checked on Feb 9, 2021

Google ScholarTM



Items in Digital Knowledge are protected by copyright, with all rights reserved, unless otherwise indicated.