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Title: Initial studies on the toxicokinetics of fumonisin BI in rats
Authors: Shephard, Gordon Seymour 
Thiel, PG 
Sydenham, Eric W. 
Keywords: Fumonisin B~ (FB,);Fusarium moniliforme Sheldon;Rats
Issue Date: 1992
Publisher: Food and Chemical Toxicology
Abstract: Fumonisin B~ (FB,), the major compound in the fumonisin group of secondary metabolites of Fusarium moniliforme Sheldon, is associated with some human and animal diseases. After intraperitoneal dosing to rats (7.5 mg/kg), FB, was rapidly absorbed and reached a maximum concentration in plasma within 20 min after injection. Thereafter, it underwent rapid removal from plasma, displaying a mono-exponential elimination phase that fitted a one-compartment model with a half-life of 18 min. Collection of 24- and 48-hr urine samples indicated that only 16% of the applied dose was eliminated unmetabolized in urine, all within the first 24-hr period following dosing. In contrast to this, a similar dose of FB I given by gavage resulted in the recovery of only 0.4% of the FBI in urine.
ISSN: 0278-6915
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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