Please use this identifier to cite or link to this item:
http://hdl.handle.net/11189/6055| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Shephard, Gordon Seymour | en_US |
| dc.contributor.author | Thiel, PG | en_US |
| dc.contributor.author | Sydenham, Eric W. | en_US |
| dc.date.accessioned | 2017-09-06T06:49:51Z | - |
| dc.date.available | 2017-09-06T06:49:51Z | - |
| dc.date.issued | 1992 | - |
| dc.identifier.issn | 0278-6915 | - |
| dc.identifier.uri | http://hdl.handle.net/11189/6055 | - |
| dc.description.abstract | Fumonisin B~ (FB,), the major compound in the fumonisin group of secondary metabolites of Fusarium moniliforme Sheldon, is associated with some human and animal diseases. After intraperitoneal dosing to rats (7.5 mg/kg), FB, was rapidly absorbed and reached a maximum concentration in plasma within 20 min after injection. Thereafter, it underwent rapid removal from plasma, displaying a mono-exponential elimination phase that fitted a one-compartment model with a half-life of 18 min. Collection of 24- and 48-hr urine samples indicated that only 16% of the applied dose was eliminated unmetabolized in urine, all within the first 24-hr period following dosing. In contrast to this, a similar dose of FB I given by gavage resulted in the recovery of only 0.4% of the FBI in urine. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Food and Chemical Toxicology | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/za/ | - |
| dc.subject | Fumonisin B~ (FB,) | en_US |
| dc.subject | Fusarium moniliforme Sheldon | en_US |
| dc.subject | Rats | en_US |
| dc.title | Initial studies on the toxicokinetics of fumonisin BI in rats | en_US |
| dc.type.patent | Article | en_US |
| Appears in Collections: | HWSci - Journal Articles (DHET subsidised) | |
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