Inclusion of dioxane and pyridine by a tricyclic host: structures, kinetics and selectivity

Abstract

The host 10,11-dihydro-5-(1-naphthyl)-5H-dibenzo[a,d]cyclohepten-5-ol forms inclusion compounds with 1,4-dioxane and pyridine, with host:guest ratios of 1:1. The structures of the inclusion compounds as well as that of the apohost have been elucidated and their packing analysed. The stability of the inclusion compounds have been measured by DSC and the kinetics of desorption have been analysed. Competition experiments show that pyridine is preferentially enclathrated over dioxane over practically the whole range of pyridine/dioxane mixtures, with a selectivity constant Kpyr:diox ≈ 9.3.