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Title: Alpha-glucosidase and alpha-amylase inhibitory activities of Novel Abietane Diterpenes from Salvia Africana-lutea
Authors: Etsassala, Ninon Geornest Eudes Ronauld 
Badmus, Jelili A. 
Waryo, Tesfaye T. 
Marnewick, Jeanine L 
Cupido, Christopher N. 
Hussein, Ahmed A. 
Iwuoha, Emmanuel I. 
Keywords: Diabetes mellitus;Lamiaceae;alpha-glucosidase;alpha-amylase;Salvia africana-lutea;terpenoids;Cape Floristic Region
Issue Date: 2019
Publisher: MDPI
Source: Etsassala, N. G. E. R., Badmus, J. A., Waryo, T. F. et al. 2019. Alpha-glucosidase and alpha-amylase inhibitory activities of Novel Abietane Diterpenes from Salvia Africana-lutea. Antioxidants, 8: 421. []
Journal: Antioxidants 
Abstract: The re-investigation of a methanolic extract of Salvia africana-lutea collected from the Cape Floristic Region, South Africa (SA), afforded four new abietane diterpenes, namely 19-acetoxy-12-methoxycarnosic acid (1), 3β-acetoxy-7α-methoxyrosmanol (2), 19-acetoxy-7α-methoxyrosmanol (3), 19-acetoxy-12-methoxy carnosol (4), and two known named clinopodiolides A (5), and B (6), in addition to four known triterpenes, oleanolic, and ursolic acids (7, 8), 11,12-dehydroursolic acid lactone (9) and β-amyrin (10). The chemical structural elucidation of the isolated compounds was determined on the basis of one and two dimensional nuclear magnetic resonance (1D and 2D NMR), high-resolution mass spectrometry (HRMS), ultra violet (UV), fourier transform infrared (IR), in comparison with literature data. The in vitro bio-evaluation against alpha-glucosidase showed strong inhibitory activities of 8, 10, and 7, with the half inhibitory concentration (IC50) values of 11.3 ± 1.0, 17.1 ± 1.0 and 22.9 ± 2.0 µg/mL, respectively, while 7 demonstrated the strongest in vitro alpha-amylase inhibitory activity among the tested compounds with IC50 of 12.5 ± 0.7 µg/mL. Additionally, some of the compounds showed significant antioxidant capacities. In conclusion, the methanolic extract of S. africana-lutea is a rich source of terpenoids, especially abietane diterpenes, with strong antioxidant and anti-diabetic activities that can be helpful to modulate the redox status of the body and could therefore be an excellent candidate for the prevention of the development of diabetes, a disease where oxidase stress plays an important role.
ISSN: 2076-3921
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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