Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7464
Title: Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemia/ reperfusion injury
Authors: Van Rooyen, Jacques 
Esterhuyse, Adriaan J 
Engelbrecht, Anna-Mart 
Du Toit, Eugene F. 
Keywords: Anti-oxidant rich oil;carotenoid;tocotrienol;tocopherol;red palm oil;oxidative stress;ischaemia/reperfusion
Issue Date: 2008
Publisher: Wiley
Source: Van Rooyen, J., Esterhuyse, A. J., Engelbrecht, A. et al. 2008. Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemia/ reperfusion injury. Asia Pacific Journal of Clinical Nutrition, 17(S1): 316-319. [http://hdl.handle.net/10072/26917]
Journal: Asia Pacific Journal of Clinical Nutrition 
Abstract: Numerous studies have reported the protective properties of carotenoid supplementation against skin and eye as- sociated diseases. However, conflicting data concerning the efficacy of -carotene in the pathogenesis of cancers and cardiovascular disease exist. It has been shown that β-carotene is an effective antioxidant on its own or in combination with other antioxidants. Red palm oil (RPO) is a potent anti-oxidant rich oil which consists of caro- tenoids, tocopherols, tocotrienols and lycopenes as well as lipid fractions such as squalene, saturated and unsatu- rated fatty acids (which maximize absorption of these anti-oxidants) and Co-enzyme Q10. and -carotene ac- count for more than 90% of the total carotene in RPO. It is known that ischaemia/reperfusion-induced injury causes an imbalance in oxygen supply which can lead to oxidative stress in the heart. It has been shown that the mitogen-activated protein kinases (MAPKs), PKB/Akt and the NO-cGMP all play vital roles in ischae- mia/reperfusion injury in the heart. Therefore, our review mainly focuses on the signaling pathways involved in functional recovery induced by a natural carotenoid oil after ischaemia/reperfusion injury
URI: http://hdl.handle.net/10072/26917
http://hdl.handle.net/11189/7464
ISSN: 1440-6047
0964-7058
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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