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Title: Immune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis
Authors: Hon, Gloudina Mary 
Hassan, Mogamat Shafick 
Janse van Rensburg, Susan 
Abel, Stefan 
Marais, De Wet 
Van Jaarsveld, Paul 
Smuts, Cornelius 
Henning, Franclo 
Erasmus, Rajiv T 
Matsha, Tandi Edith 
Keywords: Multiple sclerosis;Fatty acids;Phospholipids;C-reactive protein;Peripheral blood mononuclear cells
Issue Date: 2009
Publisher: Cambridge University Press
Source: Hon, G., Hassan, M., Janse van Rensburg, S. et al. 2009. Immune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis. British Journal of Nutrition, 102(9): 1334–1340. []
Journal: British Journal of Nutrition 
Abstract: Measurement of fatty acids in biological fluids and cell membranes including leucocytes from multiple sclerosis patients is inconsistent. The objec- tive of the present study was to investigate the fatty acid composition within the different membrane phospholipid fractions in peripheral blood mononuclear cells in multiple sclerosis patients, and correlate with severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale and Functional System Scores. The fatty acid composition of phosphatidylcholine, phosphatidylethanolamine, phosphati- dylserine, sphingomyelin and phosphatidylinositol phospholipids in the peripheral blood mononuclear cells of twenty-six multiple sclerosis and twenty-five control subjects were measured by GC, and C-reactive protein was measured in all subjects. The elongation product of 20 : 4n-6, 22 : 4n-6, was significantly decreased in membrane phosphatidylethanolamine and phosphatidylserine in multiple sclerosis patients (P¼ 0·01 and P¼ 0·03 respectively), and correlated inversely with severity of disease and C-reactive protein. Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6. Cultural and ethnic differences, as well as dietary variability, especially in a diseased state have been implicated in the differences observed in the fatty acid composition in peripheral blood mononuclear cell membranes of patients with multiple sclerosis. The present results suggest that the disease state may in part explain the reported inconsistencies in fatty acid levels in multiple sclerosis patients.
ISSN: 0007-1145
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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