Please use this identifier to cite or link to this item:
http://hdl.handle.net/11189/6898
Title: | Nanostructured TiO2 Carbon Paste Based Sensor for Determination of Methyldopa | Authors: | Garcia, Luane Ferreira Peixoto da Cunha, Carlos Eduardo Moreno, Emily Kussmaul Gonçalves Thomaz, Douglas Vieira Lobón, Germán Sanz Luque, Rafael Somerset, Vernon De Souza Gil, Eric |
Keywords: | pencil graphite;metal oxide nanostructures;low cost;phenolic drug | Issue Date: | 2018 | Publisher: | MDPI | Journal: | Pharmaceuticals | Abstract: | Methyldopa is a catecholamine widely used in the treatment of mild to moderate hypertension whose determination in pharmaceutical formulae is of upmost importance for dose precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to electro-catalytic effects promoted by metal modification, and linear response obtained by differential pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 µmol/L (Limit of Detection = 1 µmol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in determinations of similar compounds. | Description: | Article | URI: | http://hdl.handle.net/11189/6898 | DOI: | 10.3390/ph11040099 |
Appears in Collections: | Appsc - Journal Articles (DHET subsidised) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Garcia_Luane_Ferreira_Peixoto_da_Cunha_Carlos_Eduardo_Moreno_Emily_Kussmaul_Gonçalves_ Thomaz_Douglas_Vieira_Lobón_Germán_Sanz_Luque_Rafael_Somerset_Vernon_de_Souza_Gil_Eric_AppSci_2018.pdf | Article | 3.55 MB | Adobe PDF | View/Open |
Page view(s)
49
checked on Feb 9, 2021
Download(s)
7
checked on Feb 9, 2021
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License