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Title: Antimicrobial activity of Alepidea amatymbica
Authors: Lewu, Francis B 
Afolayan, A.J 
Keywords: Alepidea amatymbica;Antimicrobial;Diarrhoea;Ethnobotany;Medicinal plants
Issue Date: 2009
Publisher: Informa UK Ltd
Source: A.J. Afolayan & F.B. Lewu (2009) Antimicrobial activity of Alepidea amatymbica, Pharmaceutical Biology, 47(5): 436-439 []
Journal: Journal Pharmaceutical Biology 
Abstract: Alepidea amatymbica Eckl. & Zeyh (Apiaceae) is a medicinal plant traditionally used for the treatment of various diseases including asthma, influenza, and diarrhea in South Africa. The antimicrobial activities of the acetone and methanol extracts of the leaf, stem, rhizome, and root of the species were assessed in an effort to validate the traditional medicinal uses of this herb, especially for the treatment of infectious diseases. Ten bacterial and three fungal species were bioassayed using the agar dilution method. All the extracts demonstrated appreciable activities against three Gram-positive bacteria. These bacteria have been implicated in different respiratory diseases. The inhibitory activity of some of the extracts against pathogens implicated in diarrhea diseases further validated the use of the herb in traditional medicine. Except for acetone leaf extract against Aspergillus flavus and Aspergillus niger, all the extracts showed more than 50% mycotic inhibition with activity ranging from 51.39% on A. niger to 81.11% on Penicillium notatum at 5 mg mL−1 which was the highest concentration tested in the study. The ability of the herb to inhibit the growth of various bacteria and fungi species is an indication of the broad-spectrum antimicrobial potential of A. amatymbica; this further validates the use of the herb for various diseases by the people of the Eastern Cape.
Description: Article
DOI: 10.1080/13880200902817919
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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