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Title: In vitro Antioxidant, Antimutagenic and Genoprotective Activity of Rosa roxburghii Fruit Extract
Authors: Van der Westhuizen, FH 
Janse van Rensburg, CS 
Rautenbach, GS 
Marnewick, Jeanine L 
Loots, DT 
Huysamen, C 
Louw, R 
Pretorius, PJ 
Erasmus, E 
Keywords: Rosa roxburghii;antioxidants;antimutagenic;COMET;cytotoxicity
Issue Date: 2008
Publisher: Wiley
Source: van der Westhuizen FH, Janse van Rensburg CS, Rautenbach GS, Marnewick JL, Loots DT, Huysamen C, Louw R, Pretorius PJ & Erasmus E. 2008. In vitro Antioxidant, Antimutagenic and Genoprotective Activity of Rosa roxburghii Fruit Extract. Phytotherapy Research, 22:376–383
Journal: Phytotherapy Research, 22:376–383 
Abstract: The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. The effect on antioxidant status and protection against induced oxidative stress were also investigated using primary rat hepatocytes. A RR fruit extract containing 45 g/L total ascorbic acid and 65 g/L total polyphenols was used in this study. Dilutions up to 0.08% (v/v) increased significantly the antioxidant status in primary rat hepatocytes. The glutathione redox state was decreased with RR treatment but was increased in Chang liver cells and MT-2 lymphoblast. No cyto- or genotoxicity were observed at levels of up to 5% (v/v) of the fruit extract. In addition, a significant protection against t-BHP induced oxidative stress was observed in primary rat hepatocytes. The Ames test revealed no mutagenic activity using the Salmonella typhimurium strains TA98, TA100 and TA102. A significant antimutagenic effect of the extract was observed against the metabolic activated mutagens 2-acetylaminofluorene and aflatoxin B1 and to a lesser extent against methyl methanesulfonate. It is concluded that these results support the associated health promoting potential of Rosa Roxburghii fruit and in particular against oxidative stress.
Description: Article
DOI: 10.1002/ptr.2330
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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