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dc.contributor.authorBadmus, JAen_US
dc.contributor.authorEkpo, OEen_US
dc.contributor.authorRautenbach, Fanieen_US
dc.contributor.authorMarnewick, Jeanine Len_US
dc.contributor.authorHussein, AAen_US
dc.contributor.authorHiss, DCen_US
dc.identifier.citationBadmus JA, Ekpo OE, Rautenbach F, Marnewick JL, Hussein AA & Hiss DC. 2016. Isolation and antioxidant activity of flavonoids from Holarrhena floribunda (G.don) leaves. Acta Biochimica Polonica, 63(2), 353-358en_US
dc.description.abstractBioactive polyphenolics are ubiquitously present in plants and may play an important role in the prevention and management of certain human diseases. Three known flavonoids viz Kaemperol-3-O-rutinoside (1), quercetin-3-O-glucoside (2) and kaemperol-3-O-glucoside (3) and inseparable mixture (1:1) of quercetin-3-O-glucose/galactose (4) were isolated, and identified for the first time from Holarrhena floribunda. The antioxidant capacity using the ORAC, FRAP and TEAC assays and inhibition of lipid peroxidation were measured for isolated flavonoids. The result showed that compounds 2 and 4 showed significantly increased ORAC, TEAC, and FRAP activities with low pro-oxidant potential as well as improved lipid peroxidation inhibition levels when compared to compounds 1 and 3. The most active compounds were found to be flavonoids with a quercetin basic structure. These results imply that the isolated flavonoid glycosides are responsible for the antioxidant activity of the plant leaves and it forms the scientific basis for its traditional usage.en_US
dc.description.sponsorshipTETFund (Nigeria) for PhD travel scholarship granted to the first author.en_US
dc.description.sponsorshipSponsored, in part, by the National Research Foundation (NRF), South Africaen_US
dc.publisherPolskie Towarzystwo Biochemiczneen_US
dc.relation.ispartofActa Biochimica Polonica 63(2):353-358en_US
dc.subjectHolarrhenalarrhena floribundaen_US
dc.titleIsolation and antioxidant activity of flavonoids from Holarrhena floribunda (G.don) leavesen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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