Please use this identifier to cite or link to this item:
DC FieldValueLanguage
dc.contributor.authorMarnewick, Jeanine Len_US
dc.contributor.authorVan der Westhuizen, FHen_US
dc.contributor.authorJoubert, Elizabethen_US
dc.contributor.authorSwanevelder, Sonjaen_US
dc.contributor.authorSwart, Pen_US
dc.contributor.authorGelderblom, W.C.A.en_US
dc.identifier.citationMarnewick JL, van der Westhuizen FH, Joubert E, Swanevelder S, Swart P & Gelderblom, WCA. 2009. Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver. Food and Chemical Toxicology,7(1):220-9, doi 10.1016/j.fct.2008.11.004en_US
dc.description.abstractThe chemoprotective properties of unfermented and fermented rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) herbal teas, and green and black teas (Camellia sinensis) were investigated against fumonisin B1 (FB1) promotion in rat liver utilizing diethylnitrosamine (DEN) as cancer initiator. The various teas differently affected the clinical chemical parameters associated with liver and kidney damage associated with FB1 suggesting specific FB1/iron/polyphenolic interactions. Green tea enhanced (P < 0.05) the FB1-induced reduction of the oxygen radical absorbance capacity, while fermented herbal teas and unfermented honeybush significantly (P < 0.05) decreased FB1-induced lipid peroxidation in the liver. The teas exhibited varying effects on FB1-induced changes in the activities of catalase, glutathione peroxidase (GPx) glutathione reductase (GR) as well as the glutathione (GSH) status. Unfermented rooibos and honeybush significantly (P < 0.05) to marginally (P < 0.1) reduced the total number of foci (>10 μm), respectively, while all the teas reduced the relative amount of the larger foci. Fermentation seems to reduce the protective effect of the herbal teas. Differences in the major polyphenolic components and certain FB1/polyphenolic/tissue interactions may explain the varying effects of the different teas on the oxidative parameters, hepatotoxic effects and cancer promotion in rat liver.en_US
dc.description.sponsorshipCancer Association of South Africaen_US
dc.description.sponsorshipMedical Research Council of South Africaen_US
dc.description.sponsorshipRooibos Tea Councilen_US
dc.description.sponsorshipNational Research Foundation (Indigenous Knowledge Systems, GUN 2050353)en_US
dc.description.sponsorshipDepartment of Trade and Industry (Technology and Human Resources for Industry Programme, THRIP 2424)en_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.subjectFumonisin B1en_US
dc.subjectCancer promotionen_US
dc.subjectRat liveren_US
dc.titleChemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liveren_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
Files in This Item:
File Description SizeFormat 
Marnewick_JL_van_der_Westhuizen_FH_Joubert_E_Swanevelder_S_Swart_P_Gelderblom_WCA_H&W_2009.pdfArticle340.82 kBAdobe PDFView/Open
Show simple item record

Page view(s)

checked on Feb 9, 2021


checked on Feb 9, 2021

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons