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Title: Effects of consumption of rooibos (Aspalathus linearis) and a rooibos-derived commercial supplement on hepatic tissue Injury by tert-Butyl hydroperoxide in wistar Rats
Authors: Canda, BD 
Oguntibeju, Oluwafemi Omoniyi 
Marnewick, Jeanine L 
Keywords: Rooibos;Aspalathus linearis;tert-butyl hydroperoxide- (t-BHP-);Rooibos-derived commercial supplement
Issue Date: 2014
Publisher: Oxidative Medicine and Cellular Longevity
Source: Canda, B.D., Oguntibeju, O.O. & Marnewick, J.L. 2014. Effects of consumption of Rooibos (Aspalathus linearis) and a rooibos-derived commercial supplement on hepatic tissue injury by tert-Butyl hydroperoxide in Wistar rats. Oxidative Medicine and Cellular Longevity, 2014, 1-9 [DOI 10.1155/2014/716832].
Abstract: this study investigated the antioxidative effect of rooibos herbal tea and a rooibos-derived commercial supplement on tert-butyl hydroperoxide- (t-BHP-) induced oxidative stress in the liver. Forty male Wistar rats consumed fermented rooibos, unfermented rooibos, a rooibos-derived commercial supplement, or water for 10 weeks, while oxidative stress was induced during the last 2 weeks via intraperitoneal injection of 30 micro-mole of t-BHP per 100 g body weight. None of the beverages impaired the body weight gain of the respective animals. Rats consuming the rooibos-derived commercial supplement had the highest (P < 0.05) daily total polyphenol intake (169 mg/day) followed by rats consuming the unfermented rooibos (93.4 mg/day) and fermented rooibos (73.1 mg/day). Intake of both the derived supplement and unfermented rooibos restored the t-BHP-induced reduction and increased (P < 0.05) the antioxidant capacity status of the liver, while not impacting on lipid peroxidation. the rooibos herbal tea did not affect the hepatic antioxidant enzymes, except fermented rooibos that caused a decrease (P < 0.05) in superoxide dismutase activity. this study confirms rooibos herbal tea as good dietary antioxidant sources and, in conjunction with its many other components, offers a significantly enhanced antioxidant status of the liver in an induced oxidative stress situation.
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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