Please use this identifier to cite or link to this item:
Title: Pharmaceutical co-crystals with isonicotinamide – vitamin B3, clofibric acid, and diclofenac – and two isonicotinamide hydrates
Authors: Báthori, Nikoletta B 
Lemmerer, Andreas 
Venter, Gerhard A. 
Bourne, Susan A. 
Caira, Mino R. 
Keywords: Co-crystals;Vitamin B3;Clofibric acid;Diclofenac
Issue Date: 2011
Publisher: American Chemical Society
Source: Báthori, N.B. (2011). Pharmaceutical co-crystals with isonicotinamide – vitamin B3, clofibric acid, and diclofenac – and two isonicotinamide hydrates. Crystal Growth and Design, 11(1): 75-87. []
Abstract: The co-crystals of three industrially important pharmaceuticalmolecules, the Vitamin B group member nicotinamide (1), the antihyperlipidemic drug clofibric acid (2), and the nonsteroidal anti-inflammatory drug diclofenac (3), are synthesizedwith the co-crystal former isonicotinamide and characterized by thermal analysis and single crystalX-ray diffraction. Two dimorphic hydrates of isonicotinamide were obtained during the course of these experiments: hydrate 4 (formI) has been reported recently, and hydrate 5 (form II) is new. Both are monohydrates but differ in the number of independent molecules in the asymmetric unit, Z0=2 and 8, respectively. Form II is metastable compared to I and converts to form I in the solid state. In all three pharmaceutical co-crystals, it is the pyridine N atom of either the nicotinamide molecule in 1 or the N atom of the isonicotinamide molecule in 2 and 3 that is used in connecting the differentmolecules together, as a hydrogen bond acceptor from the amine of the isonicotinamide in 1 and the carboxylic acid protons in 2 and 3. The carboxylic acid 3 3 3 pyridine hydrogen bond is an often used supramolecular synthon.Asurvey of relevant structures in the Cambridge Structural Database of isonicotinamide and nicotinamide co-crystals is given for completeness, and the co-crystal former ability of isonicotinamide and nicotinamide was investigated by performing density functional theory calculations.
ISSN: 1528-7483
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Báthori_Nikoletta_B_Lemmerer_Andreas_Venter_Gerhard_A_Bourne_Susan_A_Caira_Mino_R_AppSci_2011.pdfMain Article760.33 kBAdobe PDFView/Open
Show full item record

Page view(s)

Last Week
Last month
checked on May 31, 2023


checked on May 31, 2023

Google ScholarTM


This item is licensed under a Creative Commons License Creative Commons