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|Title:||Pharmaceutical co-crystals with isonicotinamide – vitamin B3, clofibric acid, and diclofenac – and two isonicotinamide hydrates||Authors:||Báthori, Nikoletta B
Venter, Gerhard A.
Bourne, Susan A.
Caira, Mino R.
|Keywords:||Co-crystals;Vitamin B3;Clofibric acid;Diclofenac||Issue Date:||2011||Publisher:||American Chemical Society||Source:||Báthori, N.B. (2011). Pharmaceutical co-crystals with isonicotinamide – vitamin B3, clofibric acid, and diclofenac – and two isonicotinamide hydrates. Crystal Growth and Design, 11(1): 75-87. [https://doi.org/10.1021/cg100670k]||Abstract:||The co-crystals of three industrially important pharmaceuticalmolecules, the Vitamin B group member nicotinamide (1), the antihyperlipidemic drug clofibric acid (2), and the nonsteroidal anti-inflammatory drug diclofenac (3), are synthesizedwith the co-crystal former isonicotinamide and characterized by thermal analysis and single crystalX-ray diffraction. Two dimorphic hydrates of isonicotinamide were obtained during the course of these experiments: hydrate 4 (formI) has been reported recently, and hydrate 5 (form II) is new. Both are monohydrates but differ in the number of independent molecules in the asymmetric unit, Z0=2 and 8, respectively. Form II is metastable compared to I and converts to form I in the solid state. In all three pharmaceutical co-crystals, it is the pyridine N atom of either the nicotinamide molecule in 1 or the N atom of the isonicotinamide molecule in 2 and 3 that is used in connecting the differentmolecules together, as a hydrogen bond acceptor from the amine of the isonicotinamide in 1 and the carboxylic acid protons in 2 and 3. The carboxylic acid 3 3 3 pyridine hydrogen bond is an often used supramolecular synthon.Asurvey of relevant structures in the Cambridge Structural Database of isonicotinamide and nicotinamide co-crystals is given for completeness, and the co-crystal former ability of isonicotinamide and nicotinamide was investigated by performing density functional theory calculations.||URI:||http://hdl.handle.net/11189/3381
|Appears in Collections:||Appsc - Journal Articles (DHET subsidised)|
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