Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/8121
Title: The impact of organic hydroperoxides on rat testicular tissue and epididymal sperm
Authors: Du Plessis, Stefan Stephanus 
Aboua, Yapo Guillaume 
Brooks, Nicole L 
Keywords: Organic;hydroperoxides;rat testicular;tissue;epididymal sperm
Issue Date: 2009
Source: Du Plessis, S.S., Aboua, Y.G. & Brooks, N.L. 2009. The impact of organic hydroperoxides on rat testicular tissue and epididymal sperm. 3rd Asia-Pacific Forum on Andrology, Nanjing, China, 10-13 October. [http://www.asiaandro.com/3APFA/temp/3APFA_Proceedings.pdf]
Conference: 3rd Asia-Pacific Forum on Andrology 
Abstract: To investigate the in vivo effects of organic hydroperoxides on testicular tissue and epididymal sperm. Wistar rats (males aged 10–12 weeks) were randomly divided into nine groups and received standard rat chow and water. Animals were injected intraperitoneally with either saline ( 0.5 mL), t-butyl hydroperoxide (tbHP) (5 μmol L-1, 10 μmol L-1, 20 μmol L-1 and 40 μmol L-1; 0.5 mL) or cumene hydroperoxide (cHP) (2.5 μmol L-1, 5 μmol L-1, 10 μmol L-1 and 20 μmol L-1; 0.5 mL) over a 60-day period. Results: It was found that the epididymal sperm concentration and motility of the cHP (10 μmol L-1 and 20 μmol L-1) and tbHP (20 μmol L-1 and 40 μmol L-1) groups were significantly decreased as compared to the saline group. Furthermore, in these groups when compared to the saline group, the superoxide dismutase (SOD) concentration and glutathione (GSH) activity were also decreased, whereas the lipid peroxidation (LPO) increased in both testicular tissue and epididymal sperm. In addition epididymal sperm motility correlated negatively to LPO and positively with SOD and GSH.
URI: http://hdl.handle.net/11189/8121
Appears in Collections:HWSci - Conference Papers

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