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Title: Induction of an altered lipid phenotype by two cancer promoting treatments in rat liver
Authors: Riedel, S 
Abel, Stefan 
Swanevelder, S 
Gelderblom, Wentzel 
Keywords: Fumonisins;2-acetylaminofluorene;Cancer promotion;Hepatocyte nodules;Fatty acids;Rats
Issue Date: 2015
Publisher: Elsevier BV
Source: Riedel, S., Abel, S., Swanevelder, S. and Gelderblom, W.C.A., 2015. Induction of an altered lipid phenotype by two cancer promoting treatments in rat liver. Food and Chemical Toxicology, 78: 96-104.
Journal: Food and Chemical Toxicology 
Abstract: Changes in lipid metabolism have been associated with tumor promotion in rat liver. Similarities and differences of lipid parameters were investigated using the mycotoxin fumonisin B1 (FB1) and the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) treatments as cancer promoters in rat liver. A typical lipid phenotype was observed, including increased membranal phosphatidylethanolamine (PE) and cholesterol content, increased levels of C16:0 and monounsaturated fatty acids in PE and phosphatidylcholine (PC), as well as a decrease in C18:0 and long-chained polyunsaturated fatty acids in the PC fraction. The observed lipid changes, which likely resulted in changes in membrane structure and fluidity, may represent a growth stimulus exerted by the cancer promoters that could provide initiated cells with a selective growth advantage. This study provided insight into complex lipid profiles induced by two different cancer promoting treatments and their potential role in the development of hepatocyte nodules, which can be used to identify targets for the development of chemopreventive strategies against cancer promotion in the liver.
Appears in Collections:Journal Articles (DHET Subsidised)

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