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Title: Health claims on the benefits of moderate alcohol consumption in relation to genetic profiles
Authors: Van Velden, D. P 
Kotzé, MJ 
Blackhurst, Diane M. 
Marnewick, Jeanine L 
Kidd, M 
Keywords: Health claims;Moderate alcohol consumption;Cardiovascular disease;Apolipoprotein E (Apo E)
Issue Date: 2011
Publisher: Taylor and Francis
Abstract: A total of 43 individuals were included in a study of genetic and environmental factors associated with cardiovascular disease; seven subjects (16%) were diagnosed with the metabolic syndrome. A statistically significant association was observed between the E2 allele of the apolipoprotein E (Apo E) polymorphism and an increasing number of metabolic syndrome features (p = 0.03). Clinical and biochemical abnormalities identified could be ascribed to the combined effects of unfavorable genotypes and environmental factors known to interact with the Apo E gene. Excessive alcohol intake, high-calorie diets and smoking should be restricted in individuals with the Apo E2 and/or E4 alleles, which are associated with a significantly increased risk of cardiovascular disease.
Appears in Collections:HWSci - Journal Articles (not DHET subsidised)

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