http://hdl.handle.net/11189/3660 2026-08-16T13:03:49Z 2026-08-16T13:03:49Z REDDY, LALINI Odhav, Bharti Bhoola, KD http://hdl.handle.net/11189/3663 2018-11-05T09:55:53Z 2003-01-01T00:00:00Z

Title: Natural products for cancer prevention: a global perspective. Authors: REDDY, LALINI; Odhav, Bharti; Bhoola, KD Abstract: The control of cancer, the second leading cause of death worldwide, may benefit from the potential that resides in alternative therapies. The primary carcinogens stem from a variety of agricultural, industrial, and dietary factors. Conventional therapies cause serious side effects and, at best, merely extend the patient's lifespan by a few years. There is thus the need to utilise alternative concepts or approaches to the prevention of cancer. This review focuses on the many natural products that have been implicated in cancer prevention and that promote human health without recognisable side effects. These molecules originate from vegetables, fruits, plant extracts, and herbs.

2003-01-01T00:00:00Z Reddy, L Odhav, B Bhoola, KD http://hdl.handle.net/11189/3661 2018-06-07T06:41:50Z 2006-01-01T00:00:00Z

Title: Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Authors: Reddy, L; Odhav, B; Bhoola, KD Abstract: Aflatoxin B1 (AFB1) is a fungal toxin that has been associated with primary hepatocellular carcinoma (HCC) in humans. This study was undertaken to determine the cellular and molecular mechanisms by which the antioxidants beta-carotene and lycopene inhibit AFB1-induced toxic changes in human hepatocytes (HepG2 cells). An in vitro system was optimized to test the chemoprotective effects of lycopene and beta-carotene on HepG2 cells exposed to different concentrations of AFB1. Ultrastructurally, HepG2 cells cultured in the presence of AFB1 showed mitochondrial damage, nuclear condensation and a loss of cell-to-cell contact; the latter was reflected in the observation of dysfunctional gap junctions, resulting in a loss of cell-to-cell communication. At the genomic level, AFB1 formed AFB1-N7-guanine adducts, caused apoptotic cell death and suppressed p53 protein expression. In the presence of the carotenoids, survival of cells exposed to AFB1 was increased, and there was also a significant increase in cellular mitochondrial activity. Our results demonstrate that HepG2 cells pretreated with lycopene and beta-carotene are protected from the toxic effects of AFB1 at both the cellular and molecular levels.

2006-01-01T00:00:00Z Reddy, L Kanti, B http://hdl.handle.net/11189/3659 2018-03-16T01:01:06Z 2010-01-01T00:00:00Z

Title: Ochratoxins food contaminants: impact on human health Authors: Reddy, L; Kanti, B Abstract: Ochratoxins are secondary metabolites of Aspergillus and Penicillium, that are hazardous to health through contamination of dietary foods. Ochratoxin A (OTA) remains the single most potent member of this group of mycotoxins. OTA has a long half-life in humans and is thus easily detected in serum. Dietary intake studies have confirmed link between endemic nephrotoxicity in humans to their daily household intake of OTA. OTA has been reported to contribute to endemic nephrotoxicity and carcinogenicity in humans and animals. OTA produces renal tumours, DNA adducts and chromosomal aberrations in kidneys. OTA may be embryotoxic, teratogenic, and immunotoxic only at doses higher than those causing nephrotoxicity. The incidence of endemic nephrotoxicity has been mostly reported in northeast Europe since the early fifties. Recent studies however have warned that OTA and other toxins, such as aristolochic acid, show very similar renal pathology. There is thus the need for thorough co-occurrence studies on toxin incidence.

2010-01-01T00:00:00Z Reddy, L Singh, R http://hdl.handle.net/11189/3658 2017-12-11T23:18:23Z 2012-01-01T00:00:00Z

Title: Molecular immunogenetics of apoptosis: experimental dilemas. Authors: Reddy, L; Singh, R Abstract: There have been several research articles published on the biological and biochemical nature of apoptosis. These have included studies on the molecular genetics of apoptosis. Apart from the genes that are involved in the apoptotic cascade, there are several other genes that are either activated or inhibited when cell lines are exposed to apoptotic stimuli. This article addresses the simplicity and complexity of the genetic nature of apoptosis in a variety of cell lines.

2012-01-01T00:00:00Z