Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/8101
Title: Assessment of virus DNA in blood from patients with multiple sclerosis.
Authors: Matsha, Tandi Edith 
Hassan, Mogamat Shafick 
Van Rensburg, S. J 
Abel, S. 
Erasmus, Rajiv T 
Hon, G.M. 
Keywords: Assessment;virus DNA;blood;patients;multiple sclerosis
Issue Date: 2011
Source: Matsha, T., Hassan, M.S., Van Rensburg, S.J. et al. 2011. Assessment of virus DNA in blood from patients with multiple sclerosis. 23rd Biennial Meeting of International Society for Neurochemistry (ISN) & European Society for Neurochemistry (ESN) Athens, Greece, 28 August-1 September 2011. [https://www.neurochemistry.org/wp-content/uploads/2018/10/2011-Programme-book.pdf]
Conference: 23rd Biennial Meeting of International Society for Neurochemistry (ISN) & European Society for Neurochemistry (ESN) 
Abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system in which an infectious component has been implicated. Epstein Barr virus presence in patients with multiple sclerosis has been investigated by a number of research groups, and reports range from 0% to 100%. The aim was to investigate viral presence in patients with multiple sclerosis. Genomic DNA from 31 patients with multiple sclerosis and 30 control persons were used to establish presence of Epstein Barr virus latent genes EBNA-1, LMP-1 and Bam H-1W, as well as Human Herpes virus-6 gene U83, using PCR assays. We found a low prevalence of virus DNA in blood from both patients and controls. Epstein Barr virus in blood from both patients and controls was present in 6.5%. On the other hand Human Herpes virus-6 gene U83 was found in only 1 patient with multiple sclerosis. EBV presence in patients with MS has been investigated by a number of researchers without any consensus on percentage viral presence in patients. Similar to some research studies, our results indicated a very low presence of this virus in DNA from blood of both patients and controls.
URI: https://www.neurochemistry.org/wp-content/uploads/2018/10/2011-Programme-book.pdf
http://hdl.handle.net/11189/8101
Appears in Collections:HWSci - Conference Papers

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