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dc.contributor.authorRyffel, Bernharden_US
dc.contributor.authorJacobs, Muazzamen_US
dc.contributor.authorParida, Shreemanta K.en_US
dc.contributor.authorBotha, Taniaen_US
dc.contributor.authorTogbe, Dieudonnéeen_US
dc.contributor.authorQuesniaux, Valerieen_US
dc.identifier.citationRyffel, B., Jacobs, M., Parida, S. et al. 2006. Toll-like receptors and control of mycobacterial infection in mice. (In: Novartis Foundation Symposium 279: 127–141). []en_US
dc.descriptionBook chapteren_US
dc.description.abstractMicrobial products including mycobacterial antigens are recognized by distinct Toll-like receptors (TLRs) resulting in activation of cells of the innate immune system. Ablation of most of the TLR signalling in mice defi cient for the common adaptor protein MyD88 revealed that TLRs are crucial for the activation of an innate immune response as MyD88-defi cient mice are highly sensitive to infection with Mycobacterium tuberculosis. Despite the profound defect of the innate immune response, MyD88 defi ciency allows the emergence of an adaptive immunity. These data demonstrate that activation of multiple TLRs contributes to an effi cient innate response to mycobacteria, while MyD88- dependent signalling is dispensable to generate adaptive immunityen_US
dc.subjectMycobacterial infectionen_US
dc.subjectInfectious tuberculosisen_US
dc.subjectinnate immune systemen_US
dc.subjectadaptive immunityen_US
dc.titleToll-like receptors and control of mycobacterial infection in miceen_US
dc.typeBook chapteren_US
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