Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7486
Title: Assessment of Epstein-Barr virus in blood from patients with multiple sclerosis
Authors: Hon, Gloudina Mary 
Hassan, Mogamat Shafick 
van Rensburg, Susan Janse 
Erasmus, Rajiv T 
Matsha, Tandi Edith 
Keywords: Multiple sclerosis;Epstein-Barr virus;Anti- EBV-VCA IgG;Anti-EBV-VCA IgM;Kurtzke extended disability status scale
Issue Date: 2012
Publisher: Springer
Source: Hon, G. M., Hassan, M. S., Van Rensburg, S. J. et al. 2012. Assessment of Epstein-Barr virus in blood from patients with multiple sclerosis. Metabolic Brain Disease, 27: 311-318. [https://doi.org/10.1007/s11011-012-9292-z]
Journal: Metabolic Brain Disease 
Abstract: Viruses such as Epstein-Barr virus (EBV) which can establish latent infections in the central nervous system or the immune system have been associated with chronic neurological disorders, including multiple sclerosis. Results vary, therefore the aim of this study was to investigate the presence of EBV using both viral DNA and antibody screen- ing techniques, using PCR and ELISA assays respectively, to evaluate viral presence in blood from control subjects and patients with multiple sclerosis. Viral gene sequences for latent proteins EBNA-1 and LMP-1 and lytic gene BamH1- W were present equally in both patients and controls (<7%). Anti-EBV-VCA IgG positive cases were present in >99% of all study subjects, and anti-EBV-VCA IgG immune status ratio showed a near-significant positive correlation with the EDSS in patients with multiple sclerosis. In contrast, Anti- EBV-VCA IgM positive cases were significantly increased in patients (controls: 23.3%; patients; 41.9%; P 00.046). The IgM to IgG immune status ratio was near-significantly higher in patients with relapse episodes in the year preced- ing blood sampling (P00.058). Results from this and previ- ous studies have shown higher prevalence rates for EBV evaluating anti-EBV IgM positive cases against viral DNA positive cases. Also, IgM, an innate immune response, showed an association with relapse episodes, suggesting viral re-activation as a contributing factor to these relapses
URI: http://hdl.handle.net/11189/7486
ISSN: 1573-7365
0885-7490
DOI: https://doi.org/10.1007/s11011-012-9292-z
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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