Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7481
Title: Phospholipase A2, prostaglandin E2 and polyunsaturated fatty acid metabolic abnormalities in multiple sclerosis
Authors: Hon, Gloudina Mary 
Erasmus, Rajiv T 
Matsha, Tandi Edith 
Keywords: Multiple sclerosis;Phospholipase A2;Prostaglandin E2
Issue Date: 2013
Publisher: Japanese Society for Neuroimmunology
Source: Hon, G. M., Erasmus, R. T. & Matsha, T. E. 2013. Phospholipase A2, prostaglandin E2 and polyunsaturated fatty acid metabolic abnormalities in multiple sclerosis. Clinical and Experimental Neuroimmunology, 4(3): 288–295. [ https://doi.org/10.1111/cen3.12066]
Journal: Clinical and Experimental Neuroimmunology 
Abstract: Aim Metabolic abnormalities reported in patients with multiple sclerosis include a decrease in cell membrane fatty acid C20:4n-6. The aim of the present study was to investigate whether this decrease was associated with abnormalities in the prostaglandin E2 pathway in patients with multiple sclerosis. Methods The study population included 31 patients with multiple sclerosis and 30 healthy controls. Peripheral blood mononuclear cell membrane fatty acids were measured by gas chromatography, secretory-phospholipase A2, and prostaglandin E2 with enzyme-linked immunosorbent assays and C-reactive protein with a Beckman auto-analyser. Results Prostaglandin E2 was increased in patients (545.5 pg/mL; quartile range 585.1 pg/mL) and controls (248.2 pg/mL; quartile range 183.6 pg/mL; P = 0.0018). Phospholipase A2 was inversely associated with C20:4n-6 in patients and controls, respectively (P = 0.0398 and P = 0.0182). C-reactive protein showed a positive association with phospholipase A2 in patients (P = 0.0006), and an inverse association with prostaglandin E2 in controls (P = 0.0006). Conclusions The increase in prostaglandin E2 concentration in plasma from patients with multiple sclerosis was possibly enhanced by the positive asso- ciation between the C-reactive protein and phospholipase A2 concentra- tions present in patients; that is, active stimulation of the prostaglandin E2 pathway, which can possibly explain decreases in membrane n-6 fatty acid C20:4n-6 reported in cell membranes from patients. It is not clear from the results of the present study whether this denotes chronic inflammation in patients, but could be expected to contribute to central nervous system damage reported in patients with multiple sclerosis. (Clin. Exp. Neuroimmu- nol. doi: 10.1111/cen3.12066, October 2013)
URI: http://hdl.handle.net/11189/7481
ISSN: 1759-1961
DOI: https://doi.org/10.1111/cen3.12066
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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