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dc.contributor.authorMatsha, Tandi Edithen_US
dc.contributor.authorMasconi, Katyaen_US
dc.contributor.authorYako, Yandiswa Yolandaen_US
dc.contributor.authorHassan, Mogamat Shaficken_US
dc.contributor.authorMacharia, Muiririen_US
dc.contributor.authorErasmus, Rajiv Ten_US
dc.contributor.authorKengne, Andre Pascalen_US
dc.identifier.citationMatsha, T. E., Masconi, K., Yako, Y. Y. et al. 2012. Polymorphisms in the Non-Muscle Myosin Heavy Chain Gene (MYH9) Are Associated with Lower Glomerular Filtration Rate in Mixed Ancestry Diabetic Subjects from South Africa. PLOS One, 7(12): e52529. []en_US
dc.description.abstractObjective: Though single nucleotide polymorphisms (SNPs) in the non-muscle myosin gene (MYH9) have been reported to explain most of the excess risk of nondiabetic chronic kidney disease (CKD), in African-Americans, some studies have also shown associations with diabetic end-stage renal disease. We investigated the association of MYH9 SNPs with renal traits in a mixed-ancestry South African population prone to diabetes. Research Design and Methods: Three SNPs known to be associated with CKD (rs4821480, rs5756152 and rs12107) were genotyped using Taqman assay in 716 adults (198 with diabetes) from the Bellville-South community, Cape Town. Glomerular filtration rate was estimated (eGFR) and urinary albumin/creatinine ratio (ACR) assessed. Multivariable regressions were used to relate the SNPs with renal traits. Results: Mean age was 53.6 years, with the expected differences observed in characteristics by diabetic status. Significant associations were found between rs575152 and serum creatinine, and eGFR in the total population, and in diabetic participants (all p≤0.003), but not in non-diabetics (all p≥0.16), with significant interactions by diabetes status (interaction-p≤0.009). The association with ACR was borderline in diabetic participants (p = 0.05) and non-significant in non-diabetics (p = 0.85), with significant interaction (interaction p = 0.02). rs12107 was associated with fasting-, 2-hour glucose and HbA1c in diabetic participants only (interaction-p≤0.003), but not with renal traits. Conclusion: MYH9 SNPs were associated with renal traits only in diabetic participants in this population. Our findings and other studies suggest that MYH9 may have a broader genetic risk effect on kidney diseasesen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.subjectSingle Nucleotide Polymorphisms (SNPs)en_US
dc.subjectnon-muscle myosin gene (MYH9)en_US
dc.subjectnondiabetic chronic kidney disease (CKD)en_US
dc.subjectSouth African populationen_US
dc.titlePolymorphisms in the Non-Muscle Myosin Heavy Chain Gene (MYH9) Are Associated with Lower Glomerular Filtration Rate in Mixed Ancestry Diabetic Subjects from South Africaen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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