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dc.contributor.authorMatsha, Tandi Edithen_US
dc.contributor.authorKengne, Andre Pascalen_US
dc.contributor.authorMasconi, Katya L.en_US
dc.contributor.authorYako, Yandiswa Yen_US
dc.contributor.authorErasmus, Rajiv Ten_US
dc.identifier.citationMatsha, T. E., Kengne, A. P., Masconi, K. L. et al. 2015. APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans. BMC Genetics, 16(69). []en_US
dc.description.abstractBackground: The frequencies of apolipoprotein L1 (APOL1) variants and their associations with chronic kidney disease (CKD) vary substantially in populations from Africa. Moreover, available studies have used very small sample sizes to provide reliable estimates of the frequencies of these variants in the general population. We determined the frequency of the two APOL1 risk alleles (G1 and G2) and investigated their association with renal traits in a relatively large sample of mixed-ancestry South Africans. APOL1 risk variants (G1: rs60910145 and rs73885319; G2: rs71785313) were genotyped in 859 African mixed ancestry individuals using allele-specific TaqMan technology. Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Results: The frequencies of rs73885319, rs60910145 and rs71785313 risk alleles were respectively, 3.6 %, 3.4 %, and 5.8 %, resulting in a 1.01 % frequency of the APOL1 two-risk allele (G1:G1 or G1:G2 or G2:G2). The presence of the two-risk allele increased serum creatinine with a corresponding reduction in eGFR (either MDRD or CKD-EPI based). In dominant and log-additive genetic models, significant associations were found between rs71785313 and systolic blood pressure (both p ≤ 0.025), with a significant statistical interaction by diabetes status, p = 0.022, reflecting a negative non-significant effect in nondiabetics and a positive effect in diabetics. Conclusions: Although the APOL1 variants are not common in the mixed ancestry population of South Africa, the study does provide an indication that APOL1 variants may play a role in conferring an increased risk for renal and cardiovascular risk in this population.en_US
dc.publisherBMC (part of Springer Nature)en_US
dc.relation.ispartofBMC Geneticsen_US
dc.subjectAPOL1 polymorphismsen_US
dc.subjectChronic kidney diseasesen_US
dc.subjectBlood pressureen_US
dc.titleAPOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africansen_US
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