Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7335
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dc.contributor.authorMacharia, Muirurien_US
dc.contributor.authorKengne, Andre Pascalen_US
dc.contributor.authorBlackhurst, Diane M.en_US
dc.contributor.authorErasmus, Rajiv Ten_US
dc.contributor.authorMatsha, Tandi Edithen_US
dc.date.accessioned2020-06-24T11:57:42Z-
dc.date.available2020-06-24T11:57:42Z-
dc.date.issued2013-
dc.identifier.citationMacharia, M., Kengne, A. P., Blackhurst, D. M. et al. 2013. The impact of chronic untreated hyperglycaemia on the long-term stability of paraoxonase 1 (PON1) and antioxidant status in human sera. Journal of clinical pathology, 67(1): 55–59. [http://doi.org/10.1136/jclinpath-2013-201646]en_US
dc.identifier.issn0021-9746-
dc.identifier.issn1472-4146-
dc.identifier.urihttp://hdl.handle.net/11189/7335-
dc.description.abstractAims Paraoxonase 1 (PON1) is increasingly measured on samples that have been stored for extended durations. The impact of storage and baseline conditions on the stability of the enzyme is however not well documented. We investigated the influence of hyperglycaemia on the stability of PON1 activity and antioxidant status in human sera stored for 12 months. Methods Blood was collected from 60 individuals aged 35–80 years with chronic hyperglycaemia (HbA1c≥6.5%) or normoglycaemia (HbA1c<6.5%) in Cape Town. At baseline and after 12 months at −80°C, levels of PON1 activity ( paraoxoase and arylesterase), antioxidant activity (ferric reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC)) and lipid peroxidation (malondialdehyde and oxidised low density lipoprotein (ox-LDL)) were measured and compared.en_US
dc.language.isoenen_US
dc.publisherBMJ Groupen_US
dc.relation.ispartofJournal of clinical pathologyen_US
dc.subjectParaoxonase 1 (PON1)en_US
dc.subjectenzymeen_US
dc.subjecthyperglycaemiaen_US
dc.subjectantioxidant statusen_US
dc.subjecthuman seraen_US
dc.titleThe impact of chronic untreated hyperglycaemia on the long-term stability of paraoxonase 1 (PON1) and antioxidant status in human seraen_US
dc.identifier.doihttp://doi.org/10.1136/jclinpath-2013-201646-
dc.typeArticleen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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