Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7303
Title: Dendritic cells, T-cells and their possible role in the treatment of leukaemia and lymphoma
Authors: Davison, Glenda Mary 
Keywords: Dendritic cells;immune system;tumour surveillance;peripheral blood stem cell;leukaemia
Issue Date: 2010
Publisher: Elsevier
Source: Davison, G. M. 2010. Dendritic cells, T-cells and their possible role in the treatment of leukaemia and lymphoma. Transfusion and Apheresis Science, 42(2): 189–192. [http://doi.org/10.1016/j.transci.2010.01.018]
Journal: Transfusion and Apheresis Science 
Abstract: The immune system has the ability to control and destroy malignant calls. This has been demonstrated by the graft versus leukaemia effect and the use of donor lymphocyte infu- sions in peripheral blood stem cell transplantation. Dendritic cells are potent antigen pre- senting cells and become activated after phagocytosing and processing antigen. During this process they up-regulate MHC, co-stimulatory and adhesion molecules and have the ability to stimulate naïve T-cells. Recent evidence has shown that dendritic cells can be loaded with tumour specific antigens and can be used to generate specific anti-tumour T-cell responses. Initial clinical studies using this technology have been promising and suggest that dendritic cells and T-lymphocytes can be utilised in developing therapies which target specific malignant clones.
URI: http://hdl.handle.net/11189/7303
ISSN: 1473-0502
DOI: http://doi.org/10.1016/j.transci.2010.01.018
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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