Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7288
Title: Membrane saturated fatty acids and disease progression in Multiple Sclerosis patients
Authors: Hon, Gloudina Mary 
Hassan, Mogamat Shafick 
Van Rensburg, Susan Janse 
Abel, Stefan 
Erasmus, Rajiv T 
Matsha, Tandi Edith 
Keywords: Multiple sclerosis;Saturated fatty acids;Expanded disability status scale;C-reactive protein
Issue Date: 2009
Source: Hon, G. M., Hassan, M. S., Van Rensburg, S. J. et al. 2009. Membrane saturated fatty acids and disease progression in Multiple Sclerosis patients. Metabolic Brain Disease, 24(4): 561-568. [https://doi.org/10.1007/s11011-009-9159-0]
Journal: Metabolic Brain Disease 
Abstract: The risk of developing multiple sclerosis is associated with increased dietary intake of saturated fatty acids. We determined the fatty acid composition within the different phospholipid fractions of red blood and peripheral blood mononuclear cell membranes of 31 patients diagnosed with multiple sclerosis and 30 healthy control subjects using gas chromatography. Individual saturated fatty acids were correlated with the severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale. Significant increases were found in multiple sclerosis peripheral blood mononuclear cell membrane sphingomyelin C14:0 and phosphatidy- linositol C22:0. In the peripheral blood mononuclear cell membranes, C22:0 and C24:0 showed positive correlations, while C14:0, C16:0 and C20:0 showed inverse correlations with the Functional System Scores. In conclusion, this study is in accordance with previous studies that have shown an increase in shorter long-chain SATS in MS patients. In addition, this study also showed that higher C14:0 and C16:0 reflected better disease outcome as demonstrated by the inverse correlation with the EDSS and FSS. We have also characterized the specific SATS, that is, long-chain SATS that may increase the risk of developing MS.
URI: http://hdl.handle.net/11189/7288
ISSN: 0885-7490
DOI: https://doi.org/10.1007/s11011-009-9159-0
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Membrane saturated fatty acids.pdf173.51 kBAdobe PDFView/Open
Show full item record

Page view(s)

35
checked on Feb 9, 2021

Download(s)

3
checked on Feb 9, 2021

Google ScholarTM

Check

Altmetric


Items in Digital Knowledge are protected by copyright, with all rights reserved, unless otherwise indicated.