Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7283
Title: Erythrocyte membrane fatty acids in patients with multiple sclerosis
Authors: Hon, Gloudina Mary 
Hassan, Mogamat Shafick 
Van Rensburg, Susan Janse 
Abel, Stefan 
Marais, D.W 
Van Jaarsveld, Paul 
Smuts, CM 
Henning, F 
Erasmus, Rajiv T 
Matsha, Tandi Edith 
Keywords: multiple sclerosis;outcome measurement;relapsing/remitting
Issue Date: 2009
Publisher: SAGE Publications
Source: Hon, G. M., Hassan, M. S., Van Rensburg, S. J. et al. 2009. Erythrocyte membrane fatty acids in patients with multiple sclerosis. Multiple Sclerosis 2009, 15(6): 759–762. [https://doi.org/10.1177/1352458509103321]
Journal: Multiple Sclerosis 
Abstract: Background Reports on fatty acids levels in multiple sclerosis remain inconclusive. Objective To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale. Methods Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography. Results The membrane phosphatidylcholine C20:4n – 6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS. Conclusion Decrease in C20:4n – 6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.
URI: http://hdl.handle.net/11189/7283
ISSN: 1352-4585
DOI: https://doi.org/10.1177/1352458509103321
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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