Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7241
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dc.contributor.authorYako, Yandiswa Y.en_US
dc.contributor.authorMadubedube, Jabulisile H.en_US
dc.contributor.authorKengne, Andre P.en_US
dc.contributor.authorErasmus, Rajiv Ten_US
dc.contributor.authorPillay, Tahir Sen_US
dc.contributor.authorMatsha, Tandien_US
dc.date.accessioned2020-05-05T07:32:20Z-
dc.date.available2020-05-05T07:32:20Z-
dc.date.issued2015-
dc.identifier.citationYako, YY., Madubedube, JH., Kengne, AP. et al. 2015. Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa. African Health Sciences, 15(4):1149-60. [http://dx.doi. org/10.4314/ahs].v15i4.14]en_US
dc.identifier.issn1680-6905-
dc.identifier.urihttp://hdl.handle.net/11189/7241-
dc.description.abstractBackground: Transcription factor 7-like 2 gene (TCF7L2), fat mass and obesity-associated gene (FTO), and ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) are known risk loci for type 2 diabetes (T2DM) mostly in European populations. Objectives: To assess the association of these genes with T2DM risk in a South African mixed-ancestry population. Methods: Five hundred and sixty six participants were genotyped for ENPP1-rs997509 and -rs1044498, FTO-9941349 and -rs3751812, TCF7L2-rs12255372 and -rs7903146 polymorphisms using Taqman genotyping assays and validated by auto- mated sequencing to assess the association of the polymorphisms with cardiometabolic traits.Results: In logistic regression models adjusted for age, sex, body mass index (BMI) and insulin resistance, minor allele of rs997509 was associated with a higher risk of prevalent T2DM under a recessive model [odd ratio 4.60 (95% confidence interval: 1.07 to 19.86); p = 0.040].Under additive model, the rs7903146 [1.43 (1.00 to 2.04); p= 0.053] and rs9941349 [1.43 (1.00 to 2.04); p = 0.052] minor alleles showed marginally significant associations with a high risk of T2DM. However, only the rs7903146 alleles (p=0.011) and genotypes (p=0.025) distributions were statistically significantly different between dia- betic and non-diabetic individuals. Conclusion: Our findings demonstrate that ENPP1, TCF7L2, and FTO may predispose to T2DM in the mixed-ancestry population.en_US
dc.language.isoenen_US
dc.publisherAfrican Journals Online (AJOL)en_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.subjectType 2 diabetesen_US
dc.subjectGeneticsen_US
dc.subjectENPP1en_US
dc.subjectTCF7L2en_US
dc.subjectFTOen_US
dc.subjectAfricaen_US
dc.titleContribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africaen_US
dc.identifier.doihttp://dx.doi. org/10.4314/ahs-
dc.typeArticleen_US
Appears in Collections:Appsc - Journal Articles (not DHET subsidised)
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