Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/7241
Title: Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa
Authors: Yako, Yandiswa Y. 
Madubedube, Jabulisile H. 
Kengne, Andre P. 
Erasmus, Rajiv T 
Pillay, Tahir S 
Matsha, Tandi 
Keywords: Type 2 diabetes;Genetics;ENPP1;TCF7L2;FTO;Africa
Issue Date: 2015
Publisher: African Journals Online (AJOL)
Source: Yako, YY., Madubedube, JH., Kengne, AP. et al. 2015. Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa. African Health Sciences, 15(4):1149-60. [http://dx.doi. org/10.4314/ahs].v15i4.14]
Journal: African Health Sciences 
Abstract: Background: Transcription factor 7-like 2 gene (TCF7L2), fat mass and obesity-associated gene (FTO), and ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) are known risk loci for type 2 diabetes (T2DM) mostly in European populations. Objectives: To assess the association of these genes with T2DM risk in a South African mixed-ancestry population. Methods: Five hundred and sixty six participants were genotyped for ENPP1-rs997509 and -rs1044498, FTO-9941349 and -rs3751812, TCF7L2-rs12255372 and -rs7903146 polymorphisms using Taqman genotyping assays and validated by auto- mated sequencing to assess the association of the polymorphisms with cardiometabolic traits.Results: In logistic regression models adjusted for age, sex, body mass index (BMI) and insulin resistance, minor allele of rs997509 was associated with a higher risk of prevalent T2DM under a recessive model [odd ratio 4.60 (95% confidence interval: 1.07 to 19.86); p = 0.040].Under additive model, the rs7903146 [1.43 (1.00 to 2.04); p= 0.053] and rs9941349 [1.43 (1.00 to 2.04); p = 0.052] minor alleles showed marginally significant associations with a high risk of T2DM. However, only the rs7903146 alleles (p=0.011) and genotypes (p=0.025) distributions were statistically significantly different between dia- betic and non-diabetic individuals. Conclusion: Our findings demonstrate that ENPP1, TCF7L2, and FTO may predispose to T2DM in the mixed-ancestry population.
URI: http://hdl.handle.net/11189/7241
ISSN: 1680-6905
DOI: http://dx.doi. org/10.4314/ahs
Appears in Collections:Appsc - Journal Articles (not DHET subsidised)

Files in This Item:
File Description SizeFormat 
Contribution of ENPP1.pdf551.99 kBAdobe PDFView/Open
Show full item record

Page view(s)

22
checked on Feb 9, 2021

Google ScholarTM

Check

Altmetric


Items in Digital Knowledge are protected by copyright, with all rights reserved, unless otherwise indicated.