Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6866
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dc.contributor.authorMarnewick, JLen_US
dc.contributor.authorJoubert, Een_US
dc.contributor.authorSwart, Pen_US
dc.contributor.authorVan Der Westhuizen, Fen_US
dc.contributor.authorGelderblom, WCAen_US
dc.date.accessioned2019-02-05T10:26:18Z-
dc.date.available2019-02-05T10:26:18Z-
dc.date.issued2003-
dc.identifier.citationMarnewick JL, Joubert E, Swart P, van der Westhuizen F & Gelderblom WCA. 2003. Modulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats. Journal of Agricultural and Food Chemistry, 2003,51 (27):8113–8119, DOI: 10.1021/jf0344643en_US
dc.identifier.urihttp://hdl.handle.net/11189/6866-
dc.descriptionArticleen_US
dc.description.abstractRooibos and honeybush teas significantly (P < 0.05) enhanced the activity of cytosolic glutathione S-transferase alpha. A significant (P < 0.05) to marginal (P < 0.1) increase in the activity of the microsomal UDP-glucuronosyl transferase was obtained with unprocessed rooibos and honeybush teas, respectively. Oxidized glutathione (GSSG) levels were significantly (P < 0.05) reduced in the liver of all tea treated rats while reduced glutathione (GSH) was markedly increased in the liver of the herbal tea treated rats. These changes resulted in a significant (P < 0.05) increase in the GSH/GSSG ratio by the unprocessed, processed rooibos and unprocessed honeybush teas. Green and black teas markedly to significantly decreased the oxygen radical absorbance capacity in liver homogenates, respectively. Modulation of phase II drug metabolizing enzymes and oxidative status in the liver may be important events in the protection against adverse effects related to mutagenesis and oxidative damage.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofJournal of Agricultural and Food Chemistry, 2003,51 (27):8113–8119en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.subjectRooibos (Aspalathus lineariz) teaen_US
dc.subjecthoneybush (Cyclopia intermedia) teaen_US
dc.subjectglutathione S-transferasesen_US
dc.subjectUPD-glucuronosyl transferasesen_US
dc.subjectglutathioneen_US
dc.subjectORACen_US
dc.subjectrat liveren_US
dc.titleModulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jf0344643-
dc.identifier.pmid14690405-
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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