Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6866
Title: Modulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats
Authors: Marnewick, JL 
Joubert, E 
Swart, P 
Van Der Westhuizen, F 
Gelderblom, WCA 
Keywords: Rooibos (Aspalathus lineariz) tea;honeybush (Cyclopia intermedia) tea;glutathione S-transferases;UPD-glucuronosyl transferases;glutathione;ORAC;rat liver
Issue Date: 2003
Publisher: American Chemical Society
Source: Marnewick JL, Joubert E, Swart P, van der Westhuizen F & Gelderblom WCA. 2003. Modulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats. Journal of Agricultural and Food Chemistry, 2003,51 (27):8113–8119, DOI: 10.1021/jf0344643
Journal: Journal of Agricultural and Food Chemistry, 2003,51 (27):8113–8119 
Abstract: Rooibos and honeybush teas significantly (P < 0.05) enhanced the activity of cytosolic glutathione S-transferase alpha. A significant (P < 0.05) to marginal (P < 0.1) increase in the activity of the microsomal UDP-glucuronosyl transferase was obtained with unprocessed rooibos and honeybush teas, respectively. Oxidized glutathione (GSSG) levels were significantly (P < 0.05) reduced in the liver of all tea treated rats while reduced glutathione (GSH) was markedly increased in the liver of the herbal tea treated rats. These changes resulted in a significant (P < 0.05) increase in the GSH/GSSG ratio by the unprocessed, processed rooibos and unprocessed honeybush teas. Green and black teas markedly to significantly decreased the oxygen radical absorbance capacity in liver homogenates, respectively. Modulation of phase II drug metabolizing enzymes and oxidative status in the liver may be important events in the protection against adverse effects related to mutagenesis and oxidative damage.
Description: Article
URI: http://hdl.handle.net/11189/6866
DOI: 10.1021/jf0344643
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Show full item record

Page view(s)

17
checked on Feb 16, 2019

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons