Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6865
Title: Ex vivo modulation of chemical-induced mutagenesis by subcellular liver fractions of rats treated with rooibos (Aspalathus linearis) tea, honeybush (Cyclopia intermedia) tea, as well as green and black (Camellia sinensis) teas
Authors: Marnewick, JL 
Batenburg, W 
Swart, P 
Joubert, E 
Swanevelder, S 
Gelderblom, WCA 
Keywords: Aflatoxin B1;2-acetylaminofluorene;Mutagenesis;Ex vivo protection;Rooibos;Honeybush
Issue Date: 2004
Publisher: Elsevier
Source: Marnewick JL,, Batenburg W, Swart P, Joubert E, Swanevelder S & Gelderblom WCA, 2004. Ex vivo modulation of chemical-induced mutagenesis by subcellular liver fractions of rats treated with rooibos (Aspalathus linearis) tea, honeybush (Cyclopia intermedia) tea, as well as green and black (Camellia sinensis) teas. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 558(1-2):145-154
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 558(1-2):145-154 
Abstract: Male Fischer rats were given unprocessed (not oxidized) and processed (oxidized) rooibos and honeybush teas as well as green and black teas as a sole source of drinking fluid for 10 weeks, and sub cellular liver fractions were prepared. Cytosolic fractions of rats consuming the unprocessed herbal teas, green and black teas significantly (P<0.05) protected against 2-acetylaminofluorene (2-AAF)-induced mutagenesis in the Salmonella mutagenicity test with strain TA 98, using Aroclor 1254-induced microsomes. A marginal or no protection was obtained with the processed herbal teas. The mutagenic response of aflatoxin B1 (AFB1) against Salmonella strain TA 100 was significantly (P<0.05) inhibited by cytosolic fractions from rats treated with processed and unprocessed herbal teas, while no effect was obtained with the green and black teas. Microsomal fractions prepared from livers of rats treated with both the processed and unprocessed rooibos teas and the unprocessed honeybush tea, significantly (P<0.05) reduced the activation of AFB1 while no protection was observed against 2-AAF-induced mutagenesis. In contrast, microsomal fractions from rats treated with the green, black and unprocessed honeybush teas significantly (P<0.05) enhanced the mutagenic response of 2-AAF. None of the tea treatments significantly affected the concentration of the microsomal liver cytochrome P450.
Description: Article
URI: http://hdl.handle.net/11189/6865
DOI: 10.1016/j.mrgentox.2003.12.003
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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