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dc.contributor.authorVan der Merwe, JDen_US
dc.contributor.authorJoubert, Elizabethen_US
dc.contributor.authorRichards, ESen_US
dc.contributor.authorManley, Men_US
dc.contributor.authorSnijman, PWen_US
dc.contributor.authorMarnewick, Jeanine Len_US
dc.contributor.authorGelderblom, W.C.A.en_US
dc.identifier.citationvan der Merwe JD, Joubert E, Richards ES, Manley M, Snijman PW, Marnewick JL & Gelderblom WCA. 2006. A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 611(1–2):42-53en_US
dc.description.abstractAntimutagenic activity of aqueous extracts of the South African herbal teas, Aspalathus linearis (rooibos) and Cyclopia spp. (honeybush) was compared with that of Camellia sinensis (black, oolong and green) teas in the Salmonella mutagenicity assay using aflatoxin B1 (AFB1) and 2-acetylaminofluorene (2-AAF) as mutagens. The present study presents the first investigation on antimutagenic properties of C. subternata, C. genistoides and C. sessiliflora. The herbal teas demonstrated protection against both mutagens in the presence of metabolic activation, with the exception of “unfermented” (green/unoxidised) C. genistoides against 2-AAF, which either protected or enhanced mutagenesis depending on the concentration. Antimutagenic activity of “fermented” (oxidised) rooibos was significantly (P < 0.05) less than that of Camellia sinensis teas against AFB1, while for 2-AAF it was less (P < 0.05) than that of black tea and similar (P > 0.05) to that of oolong and green teas. Antimutagenic activity of unfermented C. intermedia and C. subternata exhibited a similar protection as fermented rooibos against AFB1. Against 2-AAF, fermented rooibos exhibited similar protective properties than unfermented C. intermedia and C. sessiliflora. Unfermented rooibos was less effective than the C. sinensis teas and fermented rooibos, but had similar (P > 0.05) antimutagenicity to that of fermented C. sessiliflora against AFB1 and fermented C. subternata against 2-AAF. Fermented C. intermedia and C. genistoides exhibited the lowest protective effect against 2-AAF, while fermented C. intermedia exhibited the lowest protection when utilising AFB1 as mutagen. Aspalathin and mangiferin, major polyphenols in rooibos and Cyclopia spp., respectively, exhibited weak to moderate protective effects when compared to the major green tea catechin, (−)epigallocatechin gallate (EGCG). Antimutagenic activity of selected herbal tea phenolic compounds indicated that they contribute towards (i) observed antimutagenic activity of the aqueous extracts against both mutagens and (ii) enhancement of the mutagenicity of 2-AAF by unfermented C. genistoides. Antimutagenic activity of the South African herbal teas was mutagen-specific, affected by fermentation and plant material, presumably due to changes and variation in phenolic composition.en_US
dc.description.sponsorshipDepartment of Trade and Industry (Technology and Human Resources for Industry Programme, project 2634)en_US
dc.description.sponsorshipThe National Research Foundation [Indigenous Knowledge Systems (GUN 2053476)]en_US
dc.description.sponsorshipNational Brands (Pty) Ltd.en_US
dc.description.sponsorshipRooibos Forumen_US
dc.relation.ispartofMutation Research/Genetic Toxicology and Environmental Mutagenesis, 611(1–2):42-53en_US
dc.subjectAntimutagenic activityen_US
dc.subjectCyclopia sppen_US
dc.subjectAspalathus linearisen_US
dc.subjectCamellia sinensisen_US
dc.titleA comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teasen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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