Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6861
Title: Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas
Authors: Marnewick, J 
Joubert, E 
Joseph, S 
Swanevelder, S 
Swart, P 
Gelderblom, W 
Keywords: Rooibos;Honeybush;TPA;Chemoprevention
Issue Date: 2005
Publisher: Elsevier
Source: Marnewick J, Joubert E, Joseph S, Swanevelder S, Swart P & Gelderblom W. 2005. Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas. Cancer Letters, 224(2):193-202, doi 10.1016/j.canlet.2004.11.014
Journal: Cancer Letters, 224(2):193-202 
Abstract: The modulating effect of ethanol/acetone (E/A) soluble fractions, prepared from methanolic extracts of processed and unprocessed rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) as well as green (Camellia sinensis) teas was established in a two-stage mouse skin carcinogenesis assay. Topical application of the tea fractions prior to the tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), on ICR mouse skin initiated with 7,12-dimethylbenz[a]anthracene (DMBA) suppressed skin tumorigenesis significantly (P<0.001) with the green tea E/A fraction exhibiting a 100% inhibition, unprocessed honeybush 90%, processed honeybush 84.2%, processed rooibos 75% and unprocessed rooibos 60%. The green tea fraction, with the highest flavanol/proanthocyanidin content, also exhibited the highest protective activity (99%) against hepatic microsomal lipid peroxidation, and completely inhibited skin tumour formation. Differences in the flavanol/proanthocyanidin and flavonol/flavone composition and/or non polyphenolic constituents are likely to be important determinants in the inhibition of tumour promotion by the herbal tea E/A fractions in mouse skin.
Description: Article
URI: http://hdl.handle.net/11189/6861
DOI: https://doi.org/10.1016/j.canlet.2004.11.014
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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