Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6762
Title: Acylphloroglucinol Derivatives from the South African Helichrysum niveum and Their Biological Activities
Authors: Popoola, OK 
Marnewick, JL 
Rautenbach, F 
Iwuoha, EI 
Hussein, AA 
Keywords: Helichrysum niveum;asteraceae;phloroglucinols;antioxidant;anti-aging
Issue Date: 2015
Publisher: MDPI
Source: Popoola OK, Marnewick JL, Rautenbach F, Iwuoha EI & Hussein, AA. 2015. Acylphloroglucinol Derivatives from the South African Helichrysum niveum and Their Biological Activities. Molecules, 20(9):17309-17324, https://doi.org/10.3390/molecules200917309
Journal: Molecules 
Abstract: Phytochemical investigation of aerial parts of Helichrysum niveum (H. niveum) using different chromatographic methods including semi-preparative HPLC afforded three new (1–3) and six known (4–10) acylphloroglucinols alongside a known dialcohol triterpene (11). The structures of the isolated compounds were characterized accordingly as 1-benzoyl-3 (3-methylbut-2-enylacetate)-phloroglucinol (helinivene A, 1), 1-benzoyl-3 (2S-hydroxyl-3-methylbut-3-enyl)-phloroglucinol (helinivene B, 2), 8-(2-methylpropanone)-3S,5,7-trihydroxyl-2,2-dimethoxychromane (helinivene C, 3), 1-(2-methylbutanone)-4-O-prenyl-phloroglucinol (4), 1-(2-methylpropanone)-4-O-prennyl-phloroglucinol (5), 1-(butanone)-3-prenyl-phloroglucinol (6), 1-(2-methylbutanone)-3-prenyl-phloroglucinol (7), 1-butanone-3-(3-methylbut-2-enylacetate)-phloroglucinol (8), 1-(2-methylpropanone)-3-prenylphloroglucinol (9), caespitate (10), and 3β-24-dihydroxyterexer-14-ene (11). Excellent total antioxidant capacities were demonstrated by helinivenes A and B (1 and 2) when measured as oxygen radicals absorbance capacity (ORAC), ferric-ion reducing antioxidant power (FRAP), trolox equivalent absorbance capacity (TEAC) and including the inhibition of Fe2+-induced lipid peroxidation (IC50 = 5.12 ± 0.90; 3.55 ± 1.92) µg/mL, while anti-tyrosinase activity at IC50 = 35.63 ± 4.67 and 26.72 ± 5.05 µg/mL were also observed for 1 and 2, respectively. This is the first chemical and in vitro biological study on H. niveum. These findings underpin new perspectives for the exploitation of these natural phenolic compounds in applications such as in the natural cosmeceutical and pharmaceutical sectors.
Description: Article
URI: http://hdl.handle.net/11189/6762
DOI: https://doi.org/10.3390/molecules200917309
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Popoola_OK_Marnewick_JL_Rautenbach_F_Iwuoha_EI_Hussein_AA_H&W_.pdfArticle743.43 kBAdobe PDFView/Open
Show full item record

Page view(s)

15
checked on Feb 21, 2019

Download(s)

3
checked on Feb 21, 2019

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons