Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6761
Title: Inhibition of Oxidative Stress and Skin Aging-Related Enzymes by Prenylated Chalcones and Other Flavonoids from Helichrysum teretifolium
Authors: Popoola, OK 
Marnewick, JL 
Rautenbach, F 
Ameer, F 
Iwuoha, EI 
Hussein, AA 
Keywords: Helichrysum teretifolium;anti-tyrosinase;anti-elastase;oxidative stress;anti-aging;flavonoids
Issue Date: 2015
Publisher: MDPI
Source: Popoola OK, Marnewick JL, Rautenbach F, Ameer F, Iwuoha, EL & Hussein, AA. 2015. Inhibition of Oxidative Stress and Skin Aging-Related Enzymes by Prenylated Chalcones and Other Flavonoids from Helichrysum teretifolium. Molecules, 20:143-7155, doi:10.3390/molecules20047143
Journal: Molecules 
Abstract: Ten flavonoid-related structures viz. heliteretifolin (1), isoxanthohumol (2), 2',4',6'-trihydroxy-3'-prenylchalcone (3), isoglabranin (4), glabranin (5), 7-methoxy-isoglabranin (6), quercetin (7), 4'-methoxyquercetin (8), 4'-methoxykaempferol (9) and mosloflavone (10) were isolated from a H. teretifolium methanolic extract and identified. One of them (compound 1) is reported for the first time from a natural source, while compounds 6, 8–10 were isolated for the first time from the genus Helichrysum. The total extract of H. teretifolium showed potent antioxidant activity. When tested for total antioxidant capacity compound 3 possesses moderate biological activity compared to 2, which displayed some of the highest TEAC values (4529.01 ± 2.44; 4170.66 ± 6.72) µM TE/g, respectively. Compounds 7 and 8 demonstrated the highest inhibitory activities on Fe2+-induced lipid peroxidation (IC50 = 2.931; 6.449 µg/mL); tyrosinase (8.092; 27.573) and elastase (43.342; 86.548). Additionally, the total antioxidant capacities measured as FRAP (4816.31 ± 7.42; 3584.17 ± 0.54) µM AAE/g, and ORAC for hydroxyl radical (7.265 ± 0.71; 6.779 ± 3.40) × 106 and peroxyl radical (17.836 ± 2.90; 12.545 ± 5.07) × 103 µM TE/g were also observed for compounds 7 and 8, respectively. In conclusion, H. teretifolium total extract represents a rich source of bioactive constituents with potent antioxidant and moderate anti-tyrosinase and anti-elastase activities that can help to avert accumulation of free radicals in the body, and could therefore be good candidates for the prevention and/or treatment of skin-related conditions, such as aging. This is the first scientific report on the chemical and biological profile of H. teretifolium.
Description: Article
URI: http://hdl.handle.net/11189/6761
DOI: 10.3390/molecules20047143
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Popoola_OK_Marnewick_JL_Rautenbach_F_Ameer_F_Iwuoha_EI_Hussein_AA_H&W_2015.pdfArticle736.36 kBAdobe PDFView/Open
Show full item record

Page view(s)

22
checked on May 19, 2019

Download(s)

2
checked on May 19, 2019

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons