Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6749
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dc.contributor.authorGelderblom, W.C.A.en_US
dc.contributor.authorSnyman, SDen_US
dc.contributor.authorAbel, Stefanen_US
dc.contributor.authorLebepe-Mazur, Sen_US
dc.contributor.authorSmuts, CMen_US
dc.contributor.authorVan der Westhuizen, Len_US
dc.contributor.authorMarasas, Walter F.Oen_US
dc.contributor.authorVictor, TCen_US
dc.contributor.authorKnasmüller, Sen_US
dc.contributor.authorHuber, Wen_US
dc.date.accessioned2019-01-22T07:22:56Z-
dc.date.available2019-01-22T07:22:56Z-
dc.date.issued1996-
dc.identifier.citationGelderblom WC, Snyman SD, Abel S, Lebepe-Mazur S, Smuts CM, van der Westhuizen L, Marasas WF, Victor TC, Knasmüller S, Huber W. 1996. Hepatotoxicity and -carcinogenicity of the fumonisins in rats. A review regarding mechanistic implications for establishing risk in humans. Advances in Experimental Medicine and Biology, 392:279-96en_US
dc.identifier.issn0065-2598-
dc.identifier.urihttp://hdl.handle.net/11189/6749-
dc.descriptionArticleen_US
dc.description.abstractCancer induction by the non-genotoxic mycotoxin, fumonisin B1, has been investigated by studying the mechanisms involved during cancer initiation and promotion in rat liver. Cancer initiation is effected through a toxic-proliferative response while the inhibitory effect on hepatocyte cell proliferation appears to be a key aspect determining cancer promotion. Dose-response effects of the fumonisins on the induction of early neoplastic lesions in both long- and short-term animal experiments have been established. The biphasic response of FB1 on hepatocyte proliferation will be discussed in relation to the known mechanisms of cancer induction by the genotoxic hepatocarcinogens. Recent investigations regarding the effect of the fumonisins on lipid biosynthesis and its inhibitory effect on hepatocyte growth stimulatory responses in vitro will be highlighted. Integration of our current knowledge regarding the carcinogenic potential of the fumonisins in setting a realistic and applicable risk assessment model for this non-genotoxic carcinogen will finally be addressed.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Experimental Medicine and Biology, 392:279-96en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.subjectnon-genotoxic mycotoxinen_US
dc.subjectCancer inductionen_US
dc.subjectfumonisin B1en_US
dc.subjectRat liveren_US
dc.subjecttoxic-proliferative responseen_US
dc.titleHepatotoxicity and -carcinogenicity of the fumonisins in rats. A review regarding mechanistic implications for establishing risk in humansen_US
dc.type.patentArticleen_US
dc.identifier.pmid8850624-
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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