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Title: Hepatotoxicity and -carcinogenicity of the fumonisins in rats. A review regarding mechanistic implications for establishing risk in humans
Authors: Gelderblom, W.C.A. 
Snyman, SD 
Abel, Stefan 
Lebepe-Mazur, S 
Smuts, CM 
Van der Westhuizen, L 
Marasas, Walter F.O 
Victor, TC 
Knasmüller, S 
Huber, W 
Keywords: non-genotoxic mycotoxin;Cancer induction;fumonisin B1;Rat liver;toxic-proliferative response
Issue Date: 1996
Publisher: Springer
Source: Gelderblom WC, Snyman SD, Abel S, Lebepe-Mazur S, Smuts CM, van der Westhuizen L, Marasas WF, Victor TC, Knasmüller S, Huber W. 1996. Hepatotoxicity and -carcinogenicity of the fumonisins in rats. A review regarding mechanistic implications for establishing risk in humans. Advances in Experimental Medicine and Biology, 392:279-96
Journal: Advances in Experimental Medicine and Biology, 392:279-96 
Abstract: Cancer induction by the non-genotoxic mycotoxin, fumonisin B1, has been investigated by studying the mechanisms involved during cancer initiation and promotion in rat liver. Cancer initiation is effected through a toxic-proliferative response while the inhibitory effect on hepatocyte cell proliferation appears to be a key aspect determining cancer promotion. Dose-response effects of the fumonisins on the induction of early neoplastic lesions in both long- and short-term animal experiments have been established. The biphasic response of FB1 on hepatocyte proliferation will be discussed in relation to the known mechanisms of cancer induction by the genotoxic hepatocarcinogens. Recent investigations regarding the effect of the fumonisins on lipid biosynthesis and its inhibitory effect on hepatocyte growth stimulatory responses in vitro will be highlighted. Integration of our current knowledge regarding the carcinogenic potential of the fumonisins in setting a realistic and applicable risk assessment model for this non-genotoxic carcinogen will finally be addressed.
Description: Article
ISSN: 0065-2598
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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