Please use this identifier to cite or link to this item:
DC FieldValueLanguage
dc.contributor.authorGamieldien, Kareemahen_US
dc.contributor.authorMaritz, Gert Sen_US
dc.identifier.citationKareemah Gamieldien & Gert S. Maritz (2004) Postnatal expression of Cytochrome P450 1A1, 2A3, and 2B1 mRNA in neonatal rat lung: influence of maternal nicotine exposure. Experimental Lung Research, 30:2, 121-133.en_US
dc.description.abstractA critical factor contributing to the etiology or modification of respiratory disease is the ability of the lung tissue to activate or inactivate chemicals. In this study, the authors investigated the effect of maternal nicotine exposure during gestation and lactation on the expression mRNA of cytochrome P450 (CYP) CYP1A1, CYP2A3, and CYP2B1. Fetal rats were exposed to nicotine via maternal administration of nicotine (1 mg/kg body weight/day, subcutaneously); after birth, neonatal rats were exposed to nicotine via the mother's milk. Lung tissue of 1-, 7-, 14-, 21-, and 49-day-old rat pups were used. From weaning on postnatal day 21 up to postnatal day 49, the offspring received no nicotine. Using RNA dot-blot techniques, our results show that CYP mRNA expression in lung tissue increased with age after birth. Maternal nicotine exposure had no influence on CYP1A1 mRNA, but resulted in a marked increase in the expression of CYP2A3 mRNA and CYP2B1 mRNA. The higher levels of CYP2A3 mRNA and CYP2B1 mRNA were maintained after weaning.en_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofExperimental Lung Researchen_US
dc.subjectCYP1A1 mRNAen_US
dc.subjectCYP2A3 mRNAen_US
dc.subjectCYP2B1 mRNAen_US
dc.subjectlung developmenten_US
dc.titlePostnatal expression of cytochrome P450 1A1, 2A3, and 2B1 mRNA in neonatal rat lung: influence of maternal nicotine exposure.en_US
dc.identifier.doiDOI: 10.1080/01902140490266484-
Appears in Collections:HWSci - Journal Articles (not DHET subsidised)
Show simple item record

Page view(s)

checked on Jul 16, 2019

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons