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Title: 2α-Acetoxy-15-acetylartemisiifolin, a new Anti-trypanosomal Sesquiterpene Lactone from Mikania guaco
Authors: Hussein Ahmed A 
Romero L 
Lopez-Perez Jose Luis 
Gupta Mahabir Prashad 
Keywords: Methanol extract;Trypanosoma cruzi;Mass spectrometry;Sesquiterpene lactone;Mikania guaco
Issue Date: 2017
Publisher: Natural Product Inc.
Journal: Natural Product Communications 
Abstract: Mikania guaco Bonpl. methanol extract showed an interesting activity against Trypanosoma cruzi with an IC50 of 4 μg/mL. Bioassay-guided fractionation of the methanol extract resulted in the isolation of a new sesquiterpene lactone, 2α-acetoxy,15-acetylartemisiifolin (1), which was shown to be active (IC50 = 25 μM) against the amastigote form of T. cruzi. The chemical structure of 1 was elucidated using 2-D NMR techniques and mass spectrometry.
Description: Article
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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